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Impact of Preexisting Anti-Adenovirus 26 Humoral Immunity on Immunogenicity of the Ad26.COV2.S Coronavirus Disease 2019 Vaccine.
Le Gars, Mathieu; Sadoff, Jerald; Struyf, Frank; Heerwegh, Dirk; Truyers, Carla; Hendriks, Jenny; Gray, Glenda; Grinsztejn, Beatriz; Goepfert, Paul A; Schuitemaker, Hanneke; Douoguih, Macaya.
  • Le Gars M; Janssen Vaccines and Prevention, Leiden, the Netherlands.
  • Sadoff J; Janssen Vaccines and Prevention, Leiden, the Netherlands.
  • Struyf F; Janssen Research and Development, Beerse, Belgium.
  • Heerwegh D; Janssen Research and Development, Beerse, Belgium.
  • Truyers C; Janssen Research and Development, Beerse, Belgium.
  • Hendriks J; Janssen Vaccines and Prevention, Leiden, the Netherlands.
  • Gray G; South African Research Council, Cape Town, South Africa.
  • Grinsztejn B; Evandro Chagas National Institute of Infectious Diseases-Fiocruz, Rio de Janeiro, Brazil.
  • Goepfert PA; Department of Medicine, University of Alabama, Birmingham, Alabama, USA.
  • Schuitemaker H; Janssen Vaccines and Prevention, Leiden, the Netherlands.
  • Douoguih M; Janssen Vaccines and Prevention, Leiden, the Netherlands.
J Infect Dis ; 226(6): 979-982, 2022 09 21.
Article in English | MEDLINE | ID: covidwho-1886441
ABSTRACT
This secondary analysis of the phase 3 ENSEMBLE trial (NCT04505722) assessed the impact of preexisting humoral immunity to adenovirus 26 (Ad26) on the immunogenicity of Ad26.COV2.S-elicited severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody levels in 380 participants in Brazil, South Africa, and the United States. Among those vaccinated in Brazil and South Africa, 31% and 66%, respectively, had prevaccination serum-neutralizing activity against Ad26, with little preexisting immunity detected in the United States. Vaccine recipients in each country had similar postvaccination spike (S) protein-binding antibody levels, indicating that baseline immunity to Ad26 has no clear impact on vaccine-induced immune responses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adenoviridae Infections / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adenoviridae Infections / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis