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COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors.
He, Xi; Liu, Chenshu; Peng, Jiangyun; Li, Zilun; Li, Fang; Wang, Jian; Hu, Ao; Peng, Meixiu; Huang, Kan; Fan, Dongxiao; Li, Na; Zhang, Fuchun; Cai, Weiping; Tan, Xinghua; Hu, Zhongwei; Deng, Xilong; Li, Yueping; Mo, Xiaoneng; Li, Linghua; Shi, Yaling; Yang, Li; Zhu, Yuanyuan; Wu, Yanrong; Liang, Huichao; Liao, Baolin; Hong, Wenxin; He, Ruiying; Li, Jiaojiao; Guo, Pengle; Zhuo, Youguang; Zhao, Lingzhai; Hu, Fengyu; Li, Wenxue; Zhu, Wei; Zhang, Zefeng; Guo, Zeling; Zhang, Wei; Hong, Xiqiang; Cai, Weikang; Gu, Lei; Du, Ziming; Zhang, Yang; Xu, Jin; Zuo, Tao; Deng, Kai; Yan, Li; Chen, Xinwen; Chen, Sifan; Lei, Chunliang.
  • He X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Liu C; Division of Vascular Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Peng J; National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Li Z; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Li F; Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Wang J; Division of Vascular Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Hu A; National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Peng M; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Huang K; Department of Obstetrics and Gynecology, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, China.
  • Fan D; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Li N; Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
  • Zhang F; Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
  • Cai W; National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Tan X; Division of Vascular Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Hu Z; National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Deng X; Division of Vascular Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Li Y; National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Mo X; Division of Vascular Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Li L; National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Shi Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Yang L; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Zhu Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Wu Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Liang H; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Liao B; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Hong W; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • He R; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Li J; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Guo P; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Zhuo Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Zhao L; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Hu F; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Li W; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Zhu W; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Zhang Z; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Guo Z; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Zhang W; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Hong X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Cai W; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Gu L; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Du Z; Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
  • Zhang Y; Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
  • Xu J; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Zuo T; Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
  • Deng K; National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Yan L; Wuhan Metware Biotechnology Co., Ltd, Wuhan, China.
  • Chen X; Wuhan Metware Biotechnology Co., Ltd, Wuhan, China.
  • Chen S; Department of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, NY, USA.
  • Lei C; Max Planck Institute for Heart and Lung Research and Cardiopulmonary Institute (CPI), Bad Nauheim, Germany.
Signal Transduct Target Ther ; 6(1): 427, 2021 12 16.
Article in English | MEDLINE | ID: covidwho-1795805
ABSTRACT
Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism. In this study, we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-related diseases, and found new-onset insulin resistance, hyperglycemia, and decreased HDL-C in these patients. Mechanistically, SARS-CoV-2 infection increased the expression of RE1-silencing transcription factor (REST), which modulated the expression of secreted metabolic factors including myeloperoxidase, apelin, and myostatin at the transcriptional level, resulting in the perturbation of glucose and lipid metabolism. Furthermore, several lipids, including (±)5-HETE, (±)12-HETE, propionic acid, and isobutyric acid were identified as the potential biomarkers of COVID-19-induced metabolic dysregulation, especially in insulin resistance. Taken together, our study revealed insulin resistance as the direct cause of hyperglycemia upon COVID-19, and further illustrated the underlying mechanisms, providing potential therapeutic targets for COVID-19-induced metabolic complications.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Insulin Resistance / Lipid Metabolism / SARS-CoV-2 / COVID-19 / Hyperglycemia / Lipids Type of study: Etiology study / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Signal Transduct Target Ther Year: 2021 Document Type: Article Affiliation country: S41392-021-00822-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Insulin Resistance / Lipid Metabolism / SARS-CoV-2 / COVID-19 / Hyperglycemia / Lipids Type of study: Etiology study / Observational study / Prognostic study / Risk factors Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Signal Transduct Target Ther Year: 2021 Document Type: Article Affiliation country: S41392-021-00822-x