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Are Dyskeratosis Congenita patients at higher risk of symptomatic COVID-19?
Dorgaleleh, Saeed; Naghipoor, Karim; Hozhabrpour, Amir; Vahidnezhad, Hassan.
  • Dorgaleleh S; Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran.
  • Naghipoor K; Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran.
  • Hozhabrpour A; Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
  • Vahidnezhad H; Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Med Hypotheses ; 163: 110843, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1796320
ABSTRACT
Dyskeratosis Congenita (DC) is a rare and heterogeneous disease. This disorder is resulted from a defect in the telomere maintenance in stem cells. Telomerase RNA component, shelterin complex, and telomerase reverse transcriptase are mutated in this disease. Many studies have previously confirmed shorter leukocyte telomere length in DC. On the other hand, the association between telomere length and Coronavirus disease 2019 (COVID-19) indicated that people with a short telomere background mostly show more severe symptoms related to COVID-19, and the mortality rate among them increases as well. Because patients with DC have an abnormally short telomere length, in the current study, we hypothesized that they are at higher risk of developing symptomatic COVID-19 that requires further clinical care.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Med Hypotheses Year: 2022 Document Type: Article Affiliation country: J.mehy.2022.110843

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Med Hypotheses Year: 2022 Document Type: Article Affiliation country: J.mehy.2022.110843