Humoral responses to SARS-CoV-2 vaccination in rituximab-treated patients depend on peripheral B cell re-population rather than the timings of the dosing
Indian Journal of Rheumatology
; 17(1):30-33, 2022.
Article
in English
| EMBASE | ID: covidwho-1798824
ABSTRACT
Introduction:
Previous exposure to Rituximab affects the immunogenicity of vaccination including that against coronavirus disease (COVID-19). However, dynamics of the effect of rituximab on vaccination are not well understood. This study aims to assess the role of timing of vaccine dosing and B-cell repopulation on vaccine seroconversion.Methods:
Autoimmune rheumatic disease (AIRD) patients treated with rituximab who had completed two doses of COVID-19 vaccination were enrolled. Peripheral B-cell counts were estimated along with the titer of immunoglobulin G antibody-directed against the receptor-binding domain of spike1 protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Antibody titers of participants were compared against B-cell re-population.Results:
Out of the 33 participants with available prevaccination B-cell counts, 11 did not have any detectable peripheral B cells before vaccination, and out of these patients, only 1 developed antibodies postvaccination, whereas, of the remaining 22, 18 (81.8%) had a positive seroconversion. Although all patients who had received the last dose of Rituximab at least 1 year before vaccination had antibodies, there was no direct correlation between time from the last dose and antibody positivity. B-cell re-population was strongly associated with seroconversion (P = 0.0001).Conclusion:
In rituximab-treated patients, humoral responses to SARS-CoV-2 vaccination depend on peripheral B-cell re-population rather than the timing of the vaccination postrituximab infusion.
adult; antibody titer; article; B lymphocyte; cell count; clinical article; controlled study; coronavirus disease 2019; drug therapy; female; human; human cell; humoral immunity; male; nonhuman; protein domain; receptor binding; rheumatic disease; seroconversion; Severe acute respiratory syndrome coronavirus 2; spike; vaccination; immunoglobulin G antibody; rituximab; vaccine
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Vaccines
Language:
English
Journal:
Indian Journal of Rheumatology
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS