NOTTO guidelines for vaccine-induced thrombotic thrombocytopenia in organ donation and transplantation
Indian Journal of Transplantation
; 16(1):3-7, 2022.
Article
in English
| EMBASE | ID: covidwho-1798826
ABSTRACT
From the context of organ donation, COVID-19 vaccine-induced thrombotic thrombocytopenia (VITT) is important as there is an ethical dilemma in utilizing versus discarding organs from potential donors succumbing to VITT. This consensus statement is an attempt by the National Organ and Tissue Transplant Organization (NOTTO) apex technical committees, India, to formulate the guidelines for deceased organ donation and transplantation in relation to VITT to help in appropriate decision-making. VITT is a rare entity, but a meticulous approach should be taken by the organ procurement organization's (OPO) team in screening such cases. All such cases must be strictly notified to the national authorities (NOTTO) as a resource for data collection and ensuring compliance with protocols in the management of adverse events following immunization. Organs from any patient who developed thrombotic events up to 4 weeks after adenoviral vector-based vaccination should be considered to be linked to VITT and investigated appropriately. The viability of the organs must be thoroughly checked by the OPO, and the final decision in relation to organ use should be decided by the expert committee of the OPO team consisting of a virologist, a hematologist, and a treating team. Considering the organ shortage, in case of suspected/confirmed VITT, both clinicians and patients should consider the riskbenefit equation based on limited experience. An appropriate written informed consent of potential recipients and family members should be obtained before the transplantation of organs from suspected or proven VITT donors.
adult; article; consensus; controlled study; coronavirus disease 2019; deceased donor; decision making; ethical dilemma; hematologist; human; human tissue; immunization; India; informed consent; organ donor; organ transplantation; practice guideline; side effect; surgery; thrombosis; vaccination; vaccine-induced immune thrombotic thrombocytopenia; virologist; adenovirus vector
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Vaccines
Language:
English
Journal:
Indian Journal of Transplantation
Year:
2022
Document Type:
Article
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