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Respiratory symptoms and radiological findings in post-acute COVID-19 syndrome.
Jutant, Etienne-Marie; Meyrignac, Olivier; Beurnier, Antoine; Jaïs, Xavier; Pham, Tai; Morin, Luc; Boucly, Athénaïs; Bulifon, Sophie; Figueiredo, Samy; Harrois, Anatole; Jevnikar, Mitja; Noël, Nicolas; Pichon, Jérémie; Roche, Anne; Seferian, Andrei; Soliman, Samer; Duranteau, Jacques; Becquemont, Laurent; Monnet, Xavier; Sitbon, Olivier; Bellin, Marie-France; Humbert, Marc; Savale, Laurent; Montani, David.
  • Jutant EM; Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Meyrignac O; INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France.
  • Beurnier A; AP-HP, Dept of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre, Hôpital Bicêtre, DMU 5 Thorinno, Le Kremlin-Bicêtre, France.
  • Jaïs X; Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Pham T; AP-HP, Service de radiologie diagnostique et interventionnelle, BioMaps, Hôpital de Bicêtre, DMU 14 Smart Imaging, Le Kremlin-Bicêtre, France.
  • Morin L; Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Boucly A; INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France.
  • Bulifon S; AP-HP, Dept of Physiology - Pulmonary Function Testing, DMU 5 Thorinno, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
  • Figueiredo S; Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Harrois A; INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France.
  • Jevnikar M; AP-HP, Dept of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre, Hôpital Bicêtre, DMU 5 Thorinno, Le Kremlin-Bicêtre, France.
  • Noël N; Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Pichon J; AP-HP, Service de Médecine Intensive-Réanimation, Hôpital de Bicêtre, DMU 4 CORREVE Maladies du Cœur et des Vaisseaux, FHU Sepsis, Le Kremlin-Bicêtre, France.
  • Roche A; Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Seferian A; AP-HP, Service de Réanimation Pédiatrique et Médecine Néonatale, Hôpital de Bicêtre, DMU3 Santé de l'Enfant et de l'Adolescent, Le Kremlin-Bicêtre, France.
  • Soliman S; Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Duranteau J; INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France.
  • Becquemont L; AP-HP, Dept of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre, Hôpital Bicêtre, DMU 5 Thorinno, Le Kremlin-Bicêtre, France.
  • Monnet X; Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Sitbon O; INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France.
  • Bellin MF; AP-HP, Dept of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre, Hôpital Bicêtre, DMU 5 Thorinno, Le Kremlin-Bicêtre, France.
  • Humbert M; Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
  • Savale L; AP-HP, Service d'anesthésie-réanimation et médecine péri-opératoire, Hôpital de Bicêtre, DMU 12 Anesthésie, réanimation, douleur, Le Kremlin-Bicêtre, France.
  • Montani D; Faculty of Medicine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
ERJ Open Res ; 8(2)2022 Apr.
Article in English | MEDLINE | ID: covidwho-1799122
ABSTRACT
Rationale The characteristics of patients with respiratory complaints and/or lung radiologic abnormalities after hospitalisation for coronavirus disease 2019 (COVID-19) are unknown. The objectives were to determine their characteristics and the relationships between dyspnoea, radiologic abnormalities and functional impairment.

Methods:

In the COMEBAC (Consultation Multi-Expertise de Bicêtre Après COVID-19) cohort study, 478 hospital survivors were evaluated by telephone 4 months after hospital discharge, and 177 who had been hospitalised in an intensive care unit (ICU) or presented relevant symptoms underwent an ambulatory evaluation. New-onset dyspnoea and cough were evaluated, and the results of pulmonary function tests and high-resolution computed tomography of the chest were collected.

Results:

Among the 478 patients, 78 (16.3%) reported new-onset dyspnoea, and 23 (4.8%) new-onset cough. The patients with new-onset dyspnoea were younger (56.1±12.3 versus 61.9±16.6 years), had more severe COVID-19 (ICU admission 56.4% versus 24.5%) and more frequent pulmonary embolism (18.0% versus 6.8%) (all p≤0.001) than patients without dyspnoea. Among the patients reassessed at the ambulatory care visit, the prevalence of fibrotic lung lesions was 19.3%, with extent <25% in 97% of the patients. The patients with fibrotic lesions were older (61±11 versus 56±14 years, p=0.03), more frequently managed in an ICU (87.9 versus 47.4%, p<0.001), had lower total lung capacity (74.1±13.7 versus 84.9±14.8% pred, p<0.001) and diffusing capacity of the lung for carbon monoxide (D LCO) (73.3±17.9 versus 89.7±22.8% pred, p<0.001). The combination of new-onset dyspnoea, fibrotic lesions and D LCO <70% pred was observed in eight out of 478 patients.

Conclusions:

New-onset dyspnoea and mild fibrotic lesions were frequent at 4 months, but the association of new-onset dyspnoea, fibrotic lesions and low D LCO was rare.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: 23120541.00479-2021

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Language: English Year: 2022 Document Type: Article Affiliation country: 23120541.00479-2021