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A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses.
Meunier, Thomas; Desmarets, Lowiese; Bordage, Simon; Bamba, Moussa; Hervouet, Kévin; Rouillé, Yves; François, Nathan; Decossas, Marion; Sencio, Valentin; Trottein, François; Tra Bi, Fézan Honora; Lambert, Olivier; Dubuisson, Jean; Belouzard, Sandrine; Sahpaz, Sevser; Séron, Karin.
  • Meunier T; University of Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
  • Desmarets L; University of Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
  • Bordage S; University of Lille, Université de Liège, Université de Picardie Jules Verne, JUNIA, UMRT 1158 BioEcoAgro, Métabolites Spécialisés d'Origine Végétale, Lille, France.
  • Bamba M; University of Lille, Université de Liège, Université de Picardie Jules Verne, JUNIA, UMRT 1158 BioEcoAgro, Métabolites Spécialisés d'Origine Végétale, Lille, France.
  • Hervouet K; UFR Sciences de la Nature, Université Nangui Abrogoua, Abidjan, Côte d'Ivoire.
  • Rouillé Y; University of Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
  • François N; University of Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
  • Decossas M; University of Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
  • Sencio V; University of Bordeaux, CBMN UMR 5248, Pessac, France.
  • Trottein F; University of Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
  • Tra Bi FH; University of Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
  • Lambert O; UFR Sciences de la Nature, Université Nangui Abrogoua, Abidjan, Côte d'Ivoire.
  • Dubuisson J; University of Bordeaux, CBMN UMR 5248, Pessac, France.
  • Belouzard S; University of Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
  • Sahpaz S; University of Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France.
  • Séron K; University of Lille, Université de Liège, Université de Picardie Jules Verne, JUNIA, UMRT 1158 BioEcoAgro, Métabolites Spécialisés d'Origine Végétale, Lille, France.
Antimicrob Agents Chemother ; 66(2): e0158121, 2022 02 15.
Article in English | MEDLINE | ID: covidwho-1799247
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak has highlighted the need for broad-spectrum antivirals against coronaviruses (CoVs). Here, pheophorbide a (Pba) was identified as a highly active antiviral molecule against human CoV-229E after bioguided fractionation of plant extracts. The antiviral activity of Pba was subsequently shown for SARS-CoV-2 and Middle East respiratory syndrome coronavirus (MERS-CoV), and its mechanism of action was further assessed, showing that Pba is an inhibitor of coronavirus entry by directly targeting the viral particle. Interestingly, the antiviral activity of Pba depends on light exposure, and Pba was shown to inhibit virus-cell fusion by stiffening the viral membrane, as demonstrated by cryoelectron microscopy. Moreover, Pba was shown to be broadly active against several other enveloped viruses and reduced SARS-CoV-2 and MERS-CoV replication in primary human bronchial epithelial cells. Pba is the first described natural antiviral against SARS-CoV-2 with direct photosensitive virucidal activity that holds potential for COVID-19 therapy or disinfection of SARS-CoV-2-contaminated surfaces.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biological Products / Middle East Respiratory Syndrome Coronavirus / COVID-19 Limits: Humans Language: English Journal: Antimicrob Agents Chemother Year: 2022 Document Type: Article Affiliation country: Aac.01581-21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biological Products / Middle East Respiratory Syndrome Coronavirus / COVID-19 Limits: Humans Language: English Journal: Antimicrob Agents Chemother Year: 2022 Document Type: Article Affiliation country: Aac.01581-21