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Megestrol Acetate in the Treatment of Post COVID-19 Fatigue in a Patient of Advanced Cancer: A Case Report and Mini Review of Literature
Indian Journal of Medical and Paediatric Oncology ; : 5, 2022.
Article in English | Web of Science | ID: covidwho-1799533
ABSTRACT
Megestrol acetate is one of the pharmacological agents used for cancer-associated fatigue. To date, there are no studies on its use in the treatment of post-COVID-19 (coronavirus disease 2019) fatigue. So, we report a case of metastatic carcinoma lung with a partial response with three cycles of palliative chemotherapy. He was contracted with mild COVID-19 infection post three cycles of his chemotherapy. Post this episode, fatigue was his main and most troublesome symptom. After a thorough clinical history, physical examination, and investigations, type 2 post-COVID-19 syndrome was diagnosed. After explaining the risks and benefits, we started the patient on low-dose megestrol acetate (160 mg/d per oral) with low to moderate benefits. However, upon increasing the dose to 480 mg/d, the benefit on the subjective quality of life was significant. Studies with a larger sample and randomized controlled trials have to be conducted to substantiate the hypothesis and actual effect of megestrol acetate in the treatment of post-COVID-19 fatigue.
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Full text: Available Collection: Databases of international organizations Database: Web of Science Type of study: Controlled clinical trial / Randomized controlled trials Topics: Long Covid Language: English Journal: Indian Journal of Medical and Paediatric Oncology Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Web of Science Type of study: Controlled clinical trial / Randomized controlled trials Topics: Long Covid Language: English Journal: Indian Journal of Medical and Paediatric Oncology Year: 2022 Document Type: Article