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Cell transcriptomic atlas of the non-human primate Macaca fascicularis.
Han, Lei; Wei, Xiaoyu; Liu, Chuanyu; Volpe, Giacomo; Zhuang, Zhenkun; Zou, Xuanxuan; Wang, Zhifeng; Pan, Taotao; Yuan, Yue; Zhang, Xiao; Fan, Peng; Guo, Pengcheng; Lai, Yiwei; Lei, Ying; Liu, Xingyuan; Yu, Feng; Shangguan, Shuncheng; Lai, Guangyao; Deng, Qiuting; Liu, Ya; Wu, Liang; Shi, Quan; Yu, Hao; Huang, Yunting; Cheng, Mengnan; Xu, Jiangshan; Liu, Yang; Wang, Mingyue; Wang, Chunqing; Zhang, Yuanhang; Xie, Duo; Yang, Yunzhi; Yu, Yeya; Zheng, Huiwen; Wei, Yanrong; Huang, Fubaoqian; Lei, Junjie; Huang, Waidong; Zhu, Zhiyong; Lu, Haorong; Wang, Bo; Wei, Xiaofeng; Chen, Fengzhen; Yang, Tao; Du, Wensi; Chen, Jing; Xu, Shibo; An, Juan; Ward, Carl; Wang, Zongren.
  • Han L; BGI-Shenzhen, Shenzhen, China.
  • Wei X; BGI-Beijing, Beijing, China.
  • Liu C; Shenzhen Bay Laboratory, Shenzhen, China.
  • Volpe G; BGI-Shenzhen, Shenzhen, China.
  • Zhuang Z; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
  • Zou X; BGI-Shenzhen, Shenzhen, China.
  • Wang Z; BGI-Beijing, Beijing, China.
  • Pan T; Shenzhen Bay Laboratory, Shenzhen, China.
  • Yuan Y; Hematology and Cell Therapy Unit, IRCCS-Istituto Tumori 'Giovanni Paolo II', Bari, Italy.
  • Zhang X; BGI-Shenzhen, Shenzhen, China.
  • Fan P; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.
  • Guo P; BGI-Shenzhen, Shenzhen, China.
  • Lai Y; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
  • Lei Y; BGI-Shenzhen, Shenzhen, China.
  • Liu X; BGI-Beijing, Beijing, China.
  • Yu F; BGI-Shenzhen, Shenzhen, China.
  • Shangguan S; BGI-Beijing, Beijing, China.
  • Lai G; BGI-Shenzhen, Shenzhen, China.
  • Deng Q; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
  • Liu Y; State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
  • Wu L; State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
  • Shi Q; State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
  • Yu H; Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Huang Y; BGI-Shenzhen, Shenzhen, China.
  • Cheng M; BGI-Beijing, Beijing, China.
  • Xu J; Shenzhen Bay Laboratory, Shenzhen, China.
  • Liu Y; State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
  • Wang M; Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
  • Wang C; Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, Guangzhou, China.
  • Zhang Y; Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, Guangzhou, China.
  • Xie D; BGI-Shenzhen, Shenzhen, China.
  • Yang Y; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
  • Yu Y; BGI-Shenzhen, Shenzhen, China.
  • Zheng H; BGI-Beijing, Beijing, China.
  • Wei Y; BGI-Shenzhen, Shenzhen, China.
  • Huang F; BGI-Beijing, Beijing, China.
  • Lei J; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
  • Huang W; BGI-Shenzhen, Shenzhen, China.
  • Zhu Z; Department of Biology, University of Copenhagen, Copenhagen, Denmark.
  • Lu H; BGI-Shenzhen, Shenzhen, China.
  • Wang B; BGI-Shenzhen, Shenzhen, China.
  • Wei X; China National GeneBank, BGI-Shenzhen, Shenzhen, China.
  • Chen F; BGI-Shenzhen, Shenzhen, China.
  • Yang T; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
  • Du W; BGI-Shenzhen, Shenzhen, China.
  • Chen J; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
  • Xu S; BGI-Shenzhen, Shenzhen, China.
  • An J; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
  • Ward C; BGI-Shenzhen, Shenzhen, China.
  • Wang Z; BGI-Shenzhen, Shenzhen, China.
Nature ; 604(7907): 723-731, 2022 04.
Article in English | MEDLINE | ID: covidwho-1799583
ABSTRACT
Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell-cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Transcriptome / Macaca fascicularis Type of study: Prognostic study Limits: Animals Language: English Journal: Nature Year: 2022 Document Type: Article Affiliation country: S41586-022-04587-3

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Transcriptome / Macaca fascicularis Type of study: Prognostic study Limits: Animals Language: English Journal: Nature Year: 2022 Document Type: Article Affiliation country: S41586-022-04587-3