Cell transcriptomic atlas of the non-human primate Macaca fascicularis.
Nature
; 604(7907): 723-731, 2022 04.
Article
in English
| MEDLINE | ID: covidwho-1799583
ABSTRACT
Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell-cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Transcriptome
/
Macaca fascicularis
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Nature
Year:
2022
Document Type:
Article
Affiliation country:
S41586-022-04587-3
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