Trained immunity-related vaccines: innate immune memory and heterologous protection against infections.
Trends Mol Med
; 28(6): 497-512, 2022 06.
Article
in English
| MEDLINE | ID: covidwho-1799777
ABSTRACT
The innate immune system is able to build memory-like features in response to certain infections or vaccines, resulting in enhanced responsiveness upon (re)challenge with the same or an unrelated pathogen, a phenomenon termed 'trained immunity'. Compared with antigen-dependent adaptive immune responses triggered by classical vaccines against specific pathogens, trained immunity-related vaccines induce enhanced innate immune responses against unrelated pathogens and provide 'heterologous protection'. Here, we discuss the heterologous effects of vaccines against infections and detail the latest insights into the cellular and molecular mechanisms mediating trained immunity. Additionally, novel vaccine strategies are suggested for fighting new pandemics in the future by taking advantage of the heterologous memory features of trained immunity.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vaccines
/
Immunologic Memory
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Trends Mol Med
Journal subject:
Molecular Biology
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS