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How can Biology of Aging Explain the Severity of COVID-19 in Older Adults.
Gallo, Antonella; Pero, Erika; Pellegrino, Simona; Macerola, Noemi; Murace, Celeste Ambra; Ibba, Francesca; Agnitelli, Maria Chiara; Landi, Francesco; Montalto, Massimo.
  • Gallo A; Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: antonella.gallo@policlinicogemelli.it.
  • Pero E; Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: pero.erika@gmail.com.
  • Pellegrino S; Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: pellegrino.simona3@gmail.com.
  • Macerola N; Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: noemi.macerola@gmail.com.
  • Murace CA; Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: celeste.murace@gmail.com.
  • Ibba F; Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: franci.ibba@gmail.com.
  • Agnitelli MC; Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy. Electronic address: mariachiaragnitelli@icloud.com.
  • Landi F; Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: francesco.landi@policlinicogemelli.it.
  • Montalto M; Fondazione Policlinico Universitario A. Gemelli, IRCSS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: massimo.montalto@unicatt.it.
Clin Geriatr Med ; 38(3): 461-472, 2022 08.
Article in English | MEDLINE | ID: covidwho-1914223
ABSTRACT
Aging has been identified as one of the most relevant risk factors for poor outcomes in COVID-19 infection. Since now, different mechanisms responsible for worse outcomes in the elderly have been proposed, which include the remodeling of immune system, the higher prevalence of malnutrition and sarcopenia, the increased burden of multimorbidity, and, to a lesser extent, the direct effects of age on the respiratory system and hormonal profile. It seems that the interplay between all these causes, rather than the individual pathophysiological mechanism, explains the increased severity of the disease with age.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunosenescence / COVID-19 Type of study: Observational study / Prognostic study Limits: Aged / Humans Language: English Journal: Clin Geriatr Med Journal subject: Geriatrics Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunosenescence / COVID-19 Type of study: Observational study / Prognostic study Limits: Aged / Humans Language: English Journal: Clin Geriatr Med Journal subject: Geriatrics Year: 2022 Document Type: Article