Crystal structure of SARS-CoV 3C-like protease with baicalein.
Biochem Biophys Res Commun
; 611: 190-194, 2022 06 30.
Article
in English
| MEDLINE | ID: covidwho-1800190
ABSTRACT
The 3C-like protease (Mpro, 3CLpro) plays a key role in the replication process in coronaviruses (CoVs). The Mpro is an essential enzyme mediates CoVs replication and is a promising target for development of antiviral drugs. Until now, baicalein has been shown the specific activity for SARS-CoV Mpro in vitro experiments. In this study, we resolved the SARS-CoV Mpro with baicalein by X-ray diffraction at 2.25 Å (PDB code 7XAX), which provided a structural basis for the research and development of baicalein as an anti-CoVs drug.
Keywords
Full text:
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Collection:
International databases
Database:
MEDLINE
Main subject:
Severe acute respiratory syndrome-related coronavirus
Language:
English
Journal:
Biochem Biophys Res Commun
Year:
2022
Document Type:
Article
Affiliation country:
J.bbrc.2022.04.086
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