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Blood Purification Techniques, Inflammatory Mediators and Mortality in COVID-19 Patients.
Hashemian, Seyed Mohammadreza; Shafigh, Navid; Afzal, Golnaz; Jamaati, Hamidreza; Mortaz, Esmaeil; Tabarsi, Payam; Marjani, Majid; Malekmohammad, Majid; Dastan, Farzaneh; Mortazavi, Seyed Mehdi; Sadr, Makan; Idani, Esmaeil; Khoundabi, Batoul; Mohamadnia, Abdolreza; Abedini, Atefeh; Kiani, Arda; Moniri, Afshin; Nadji, Seyed Alireza; Yassari, Fatemeh; Mokhber Dezfuli, Mojtaba; Pourabdollah, Mihan; Varahram, Mohammad; Eshaghi, Faezeh; Malekpour, Mahdi; Velayati, Aliakbar.
  • Hashemian SM; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Shafigh N; Department of Anesthesiology and Critical Care Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Afzal G; Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Jamaati H; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mortaz E; Clinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Tabarsi P; Clinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Marjani M; Clinical Tuberculosis and Epidemiology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Malekmohammad M; Tracheal Diseases Research Center (TDRC), NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Dastan F; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mortazavi SM; Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Sadr M; Department of Nursing, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Idani E; Virology Research Center (VRC), NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Khoundabi B; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mohamadnia A; Iran-Helal Institute of Applied-Science and Technology, Research Center for Health Management in Mass Gathering, Red Crescent Society of the Islamic Republic of Iran, Tehran, Iran.
  • Abedini A; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Kiani A; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Moniri A; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Nadji SA; Virology Research Center (VRC), NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Yassari F; Virology Research Center (VRC), NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Mokhber Dezfuli M; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Pourabdollah M; Lung Transplantation Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Varahram M; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Eshaghi F; Mycobacteriology Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Malekpour M; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Velayati A; Geisinger Medical Center, Danville, PA, USA.
Tanaffos ; 19(4): 291-299, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-1801409
Semantic information from SemMedBD (by NLM)
1. Inflammation Mediators TREATS COVID-19
Subject
Inflammation Mediators
Predicate
TREATS
Object
COVID-19
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Inflammation Mediators TREATS Patients
Subject
Inflammation Mediators
Predicate
TREATS
Object
Patients
4. Study USES Hemoperfusion
Subject
Study
Predicate
USES
Object
Hemoperfusion
5. Study USES Continuous Renal Replacement Therapy
Subject
Study
Predicate
USES
Object
Continuous Renal Replacement Therapy
6. Respiratory Distress Syndrom PROCESS_OF C0030705
Subject
Respiratory Distress Syndrom
Predicate
PROCESS_OF
Object
C0030705
7. Serum LOCATION_OF creatinine
Subject
Serum
Predicate
LOCATION_OF
Object
creatinine
8. Continuous Renal Replacement Therapy AFFECTS Patients
Subject
Continuous Renal Replacement Therapy
Predicate
AFFECTS
Object
Patients
9. Inflammation Mediators TREATS COVID-19
Subject
Inflammation Mediators
Predicate
TREATS
Object
COVID-19
10. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
11. Inflammation Mediators TREATS Patients
Subject
Inflammation Mediators
Predicate
TREATS
Object
Patients
12. Study USES Hemoperfusion
Subject
Study
Predicate
USES
Object
Hemoperfusion
13. Study USES Continuous Renal Replacement Therapy
Subject
Study
Predicate
USES
Object
Continuous Renal Replacement Therapy
14. Respiratory Distress Syndrome, Adult PROCESS_OF Patients
Subject
Respiratory Distress Syndrome, Adult
Predicate
PROCESS_OF
Object
Patients
15. Serum LOCATION_OF creatinine
Subject
Serum
Predicate
LOCATION_OF
Object
creatinine
16. Continuous Renal Replacement Therapy AFFECTS Patients
Subject
Continuous Renal Replacement Therapy
Predicate
AFFECTS
Object
Patients
ABSTRACT

BACKGROUND:

Inflammatory mediators are an important component in the pathophysiology of the coronavirus disease 2019 (COVID-19). This study aimed to assess the effects of reducing inflammatory mediators using hemoperfusion (HP) and continuous renal replacement therapy (CRRT) on the mortality of patients with COVID-19. MATERIALS AND

METHODS:

Twelve patients with confirmed diagnosis of COVID-19 were included. All patients had acute respiratory distress syndrome (ARDS). Patients were divided into three groups, namely, HP, CRRT and HP+CRRT. The primary outcome was mortality and the secondary outcomes were oxygenation and reduction in inflammatory mediators at the end of the study.

RESULTS:

Patients were not different at baseline in demographics, inflammatory cytokine levels, and the level of acute phase reactants. Half of the patients (3 out of 6) in the HP+CRRT group survived along with the survival of one patient (1 out of 2) in the HP group. All four patients in the CRRT group died. Serum creatinine (SCr), Interleukin-1 (IL1), Interleukin-6 (IL6), Interleukin-8 (IL8), partial pressure of oxygen (PaO2), O2 saturation (O2 sat), and hemodynamic parameters improved over time in HP+CRRT and CRRT groups, but no significant difference was observed in the HP group (All Ps > 0.05).

CONCLUSION:

Combined HP and CRRT demonstrated the best result in terms of mortality, reduction of inflammatory mediators and oxygenation. Further investigations are needed to explore the role of HP+CRRT in COVID-19 patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Journal: Tanaffos Year: 2020 Document Type: Article Affiliation country: Iran

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Journal: Tanaffos Year: 2020 Document Type: Article Affiliation country: Iran