Your browser doesn't support javascript.
Comparison between the double-syringe and the single-syringe techniques of adenosine administration for terminating supraventricular tachycardia: A pilot, randomized controlled trial.
Kotruchin, Praew; Chaiyakhan, Itchaya-On; Kamonsri, Phimonphorn; Chantapoh, Wittawin; Serewiwattana, Nattapat; Kaweenattayanon, Nayawadee; Narangsiya, Nattacha; Lorcharassriwong, Piyangkul; Korsakul, Kittithat; Thawepornpuriphong, Punnapat; Tirapuritorn, Tanachoke; Mitsungnern, Thapanawong.
  • Kotruchin P; Department of Emergency Medicine, Faculty of Medicine, Khon Kaen University, Muang, Khon Kaen, Thailand.
  • Chaiyakhan IO; Department of Emergency Medicine, Faculty of Medicine, Khon Kaen University, Muang, Khon Kaen, Thailand.
  • Kamonsri P; Emergency Medicine Unit, Srisaket Hospital, Muang, Srisaket, Thailand.
  • Chantapoh W; Kukan Hospital, Srisaket, Thailand.
  • Serewiwattana N; Emergency Medicine Unit, Queen Sirikit Heart Center of the Northeast, Khon Kaen, Thailand.
  • Kaweenattayanon N; Emergency Medicine Unit, Khon Kaen Hospital, Muang, Khon Kaen, Thailand.
  • Narangsiya N; Emergency Medicine Unit, Srisaket Hospital, Muang, Srisaket, Thailand.
  • Lorcharassriwong P; Yangchumnoi Hospital, Srisaket, Thailand.
  • Korsakul K; Kalasin Hospital, Kalasin, Thailand.
  • Thawepornpuriphong P; Jun Hospital, Payao, Thailand.
  • Tirapuritorn T; Wisetchaicharn Hospital, Angthong, Thailand.
  • Mitsungnern T; Department of Emergency Medicine, Faculty of Medicine, Khon Kaen University, Muang, Khon Kaen, Thailand.
Clin Cardiol ; 45(5): 583-589, 2022 May.
Article in English | MEDLINE | ID: covidwho-1802116
ABSTRACT

BACKGROUND:

Adenosine has been recommended as a first-line treatment for stable supraventricular tachycardia (SVT). Standard guidelines recommend 6-mg of adenosine administered intravenously (IV) with an immediate 20-ml IV bolus of normal saline solution (NSS; double syringe technique [DST]). However, a newly proposed single-syringe technique (SST), in which adenosine is diluted with an up to 20 ml IV bolus of NSS, was found to be beneficial.

HYPOTHESIS:

We hypothesized that the SST was noninferior to the DST for terminating stable SVT.

METHODS:

A pilot multicenter, single-blind, randomized controlled study was conducted at nine hospitals in north and northeast Thailand. Thirty patients who were diagnosed with stable SVT were randomized into two groups of 15, with one receiving adenosine via the DST and the other via the SST. We examined SVT termination, the average successful dose, and the complication rate of each group. Analyses were based on the intention-to-treat principle.

RESULT:

The termination rate was 93.3% in the DST and 100% in the SST group (p = 1.000), and the success rate of the first 6-mg dose of adenosine was 73.3% and 80%, respectively (p = 1.000). The total administered dose was 8.6 ± 5.1 mg in the DST group and 7.6 ± 4.5 mg in the SST group (p = .608). No complications were found in either group.

CONCLUSIONS:

The SST was non-inferior to the DST for termination of SVT. However, a further definitive study with a larger sample size is required.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Tachycardia, Paroxysmal / Tachycardia, Supraventricular Type of study: Diagnostic study / Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Clin Cardiol Year: 2022 Document Type: Article Affiliation country: Clc.23820

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Tachycardia, Paroxysmal / Tachycardia, Supraventricular Type of study: Diagnostic study / Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Clin Cardiol Year: 2022 Document Type: Article Affiliation country: Clc.23820