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The expression patterns of MALAT-1, NEAT-1, THRIL, and miR-155-5p in the acute to the post-acute phase of COVID-19 disease.
Abbasi-Kolli, Mohammad; Sadri Nahand, Javid; Kiani, Seyed Jalal; Khanaliha, Khadijeh; Khatami, AliReza; Taghizadieh, Mohammad; Torkamani, Ali Rajabi; Babakhaniyan, Kimiya; Bokharaei-Salim, Farah.
  • Abbasi-Kolli M; Iran University of Medical Sciences, Deputy of Health, Tehran, Iran.
  • Sadri Nahand J; Tabriz University of Medical Sciences, Infectious and Tropical Diseases Research Center, Tabriz, Iran.
  • Kiani SJ; Iran University of Medical Sciences, School of Medicine, Department of Virology, Tehran, Iran.
  • Khanaliha K; University of Medical Sciences, Institute of Immunology and Infectious Diseases, Research Center of Pediatric Infectious Diseases, Tehran, Iran.
  • Khatami A; Iran University of Medical Sciences, School of Medicine, Department of Virology, Tehran, Iran.
  • Taghizadieh M; Tabriz University of Medical Sciences, Center for Women's Health Research Zahra, School of Medicine, Department of Pathology, Tabriz, Iran.
  • Torkamani AR; Tehran University of Medical Sciences, School of Medicine, Department of Clinical Biochemistry, Tehran, Iran.
  • Babakhaniyan K; Iran University of Medical Sciences, School of Nursing and Midwifery, Department of Medical Surgical Nursing, Tehran, Iran.
  • Bokharaei-Salim F; Iran University of Medical Sciences, School of Medicine, Department of Virology, Tehran, Iran. Electronic address: bokharaei.f@iums.ac.ir.
Braz J Infect Dis ; 26(3): 102354, 2022.
Article in English | MEDLINE | ID: covidwho-1803609
ABSTRACT

INTRODUCTION:

One of the hallmarks of COVID-19 is overwhelming inflammation, which plays a very important role in the pathogenesis of COVID-19. Thus, identification of inflammatory factors that interact with the SARS-CoV-2 can be very important to control and diagnose the severity of COVID-19. The aim of this study was to investigate the expression patterns of inflammation-related non-coding RNAs (ncRNAs) including MALAT-1, NEAT-1, THRIL, and miR-155-5p from the acute phase to the recovery phase of COVID-19.

METHODS:

Total RNA was extracted from Peripheral Blood Mononuclear Cell (PBMC) samples of 20 patients with acute COVID-19 infection and 20 healthy individuals and the expression levels of MALAT-1, NEAT-1, THRIL, and miR-155-5p were evaluated by real-time PCR assay. Besides, in order to monitor the expression pattern of selected ncRNAs from the acute phase to the recovery phase of COVID-19 disease, the levels of ncRNAs were re-measured 6‒7 weeks after the acute phase.

RESULT:

The mean expression levels of MALAT-1, THRIL, and miR-155-5p were significantly increased in the acute phase of COVID-19 compared with a healthy control group. In addition, the expression levels of MALAT-1 and THRIL in the post-acute phase of COVID-19 were significantly lower than in the acute phase of COVID-19. According to the ROC curve analysis, these ncRNAs could be considered useful biomarkers for COVID-19 diagnosis and for discriminating between acute and post-acute phase of COVID-19.

DISCUSSION:

Inflammation-related ncRNAs (MALAT-1, THRIL, and miR-150-5p) can act as hopeful biomarkers for the monitoring and diagnosis of COVID-19 disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: MicroRNAs / RNA, Long Noncoding / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Braz J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.bjid.2022.102354

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Full text: Available Collection: International databases Database: MEDLINE Main subject: MicroRNAs / RNA, Long Noncoding / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Braz J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.bjid.2022.102354