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Glucometabolic changes influence hospitalization and outcome in patients with COVID-19: An observational cohort study.
Clausen, Clara L; Leo-Hansen, Christian; Faurholt-Jepsen, Daniel; Krogh-Madsen, Rikke; Ritz, Christian; Kirk, Ole; Jørgensen, Henrik L; Benfield, Thomas; Almdal, Thomas P; Snorgaard, Ole.
  • Clausen CL; Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark. Electronic address: clara.lundetoft.clausen@regionh.dk.
  • Leo-Hansen C; Department of Infectious Diseases, Rigshospitalet, Denmark.
  • Faurholt-Jepsen D; Department of Infectious Diseases, Rigshospitalet, Denmark.
  • Krogh-Madsen R; Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Denmark.
  • Ritz C; National Institute of Public Health, University of Southern Denmark - Copenhagen, Denmark.
  • Kirk O; Department of Infectious Diseases, Rigshospitalet, Denmark; Department of Clinical Medicine, Faculty of Health and Medicines, University of Copenhagen - Copenhagen, Denmark.
  • Jørgensen HL; Department of Clinical Biochemistry, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medicines, University of Copenhagen - Copenhagen, Denmark.
  • Benfield T; Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medicines, University of Copenhagen - Copenhagen, Denmark.
  • Almdal TP; Department of Endocrinology, Copenhagen University Hospital - Rigshospitalet, Denmark; Department of Immunology and Microbiology, Faculty of Health and Medicines, University of Copenhagen, Denmark.
  • Snorgaard O; Department of Medical Endocrinology, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
Diabetes Res Clin Pract ; 187: 109880, 2022 May.
Article in English | MEDLINE | ID: covidwho-1803865
ABSTRACT

AIMS:

The aim was to report the prevalence of diabetes status in patients hospitalized with COVID-19 and assess the association between the glucometabolic status at admission and 90-day mortality.

METHODS:

Consecutive patients hospitalized with COVID-19 were included in the study. All participants included had an HbA1c measurement 60 days prior to or within 7 days after admission. We studied the association between diabetes status, the glycemic gap (difference between admission and habitual status), admission plasma-glucose, and mortality using Cox proportional hazards regression.

RESULTS:

Of 674 patients included, 114 (17%) had normal glucose level, 287 (43%) had pre-diabetes, 74 (11%) had new-onset, and 199 (30%) had diagnosed diabetes. No association between diabetes status, plasma-glucose at admission, and mortality was found. Compared to the 2nd quartile (reference) of glycemic-gap, those with the highest glycemic gap had increased mortality (3rd (HR 2.38 [1.29-4.38], p = 0.005) and 4th quartile (HR 2.48 [1.37-4.52], p = 0.002).

CONCLUSION:

Abnormal glucose metabolism was highly prevalent among patients hospitalized with COVID-19. Diabetes status per se or admission plasma-glucose was not associated with a poorer outcome. However, a high glycemic gap was associated with increased risk of mortality, suggesting that, irrespective of diabetes status, glycemic stress serves as an important prognostic marker for mortality.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / COVID-19 / Hyperglycemia Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Diabetes Res Clin Pract Journal subject: Endocrinology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / COVID-19 / Hyperglycemia Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: Diabetes Res Clin Pract Journal subject: Endocrinology Year: 2022 Document Type: Article