Your browser doesn't support javascript.
Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost.
Muecksch, Frauke; Wang, Zijun; Cho, Alice; Gaebler, Christian; Ben Tanfous, Tarek; DaSilva, Justin; Bednarski, Eva; Ramos, Victor; Zong, Shuai; Johnson, Brianna; Raspe, Raphael; Schaefer-Babajew, Dennis; Shimeliovich, Irina; Daga, Mridushi; Yao, Kai-Hui; Schmidt, Fabian; Millard, Katrina G; Turroja, Martina; Jankovic, Mila; Oliveira, Thiago Y; Gazumyan, Anna; Caskey, Marina; Hatziioannou, Theodora; Bieniasz, Paul D; Nussenzweig, Michel C.
  • Muecksch F; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
  • Wang Z; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Cho A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Gaebler C; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Ben Tanfous T; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • DaSilva J; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
  • Bednarski E; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
  • Ramos V; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Zong S; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Johnson B; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Raspe R; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Schaefer-Babajew D; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Shimeliovich I; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Daga M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Yao KH; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Schmidt F; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
  • Millard KG; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Turroja M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Jankovic M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Oliveira TY; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
  • Hatziioannou T; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA. thatziio@rockefeller.edu.
  • Bieniasz PD; Laboratory of Retrovirology, The Rockefeller University, New York, NY, USA. pbieniasz@rockefeller.edu.
  • Nussenzweig MC; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA. pbieniasz@rockefeller.edu.
Nature ; 607(7917): 128-134, 2022 07.
Article in English | MEDLINE | ID: covidwho-1805634
ABSTRACT
The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent individuals1-3. Despite the reduced protection from infection, individuals who received three doses of an mRNA vaccine were highly protected from more serious consequences of infection4. Here we examine the memory B cell repertoire in a longitudinal cohort of individuals receiving three mRNA vaccine doses5,6. We find that the third dose is accompanied by an increase in, and evolution of, receptor-binding domain (RBD)-specific memory B cells. The increase is due to expansion of memory B cell clones that were present after the second dose as well as the emergence of new clones. The antibodies encoded by these cells showed significantly increased potency and breadth when compared with antibodies obtained after the second dose. Notably, the increase in potency was especially evident among newly developing clones of memory cells, which differed from persisting clones in targeting more conserved regions of the RBD. Overall, more than 50% of the analysed neutralizing antibodies in the memory compartment after the third mRNA vaccine dose neutralized the Omicron variant. Thus, individuals receiving three doses of an mRNA vaccine have a diverse memory B cell repertoire that can respond rapidly and produce antibodies capable of clearing even diversified variants such as Omicron. These data help to explain why a third dose of a vaccine that was not specifically designed to protect against variants is effective against variant-induced serious disease.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunization, Secondary / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / MRNA Vaccines / Memory B Cells Topics: Vaccines / Variants Limits: Humans Language: English Journal: Nature Year: 2022 Document Type: Article Affiliation country: S41586-022-04778-y

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunization, Secondary / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / MRNA Vaccines / Memory B Cells Topics: Vaccines / Variants Limits: Humans Language: English Journal: Nature Year: 2022 Document Type: Article Affiliation country: S41586-022-04778-y