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Reduced Cell Surface Levels of C-C Chemokine Receptor 5 and Immunosuppression in Long Coronavirus Disease 2019 Syndrome.
Gaylis, Norman B; Ritter, Angela; Kelly, Scott A; Pourhassan, Nader Z; Tiwary, Meenakshi; Sacha, Jonah B; Hansen, Scott G; Recknor, Christopher; Yang, Otto O.
  • Gaylis NB; Arthritis & Rheumatic Disease Specialties, Aventura, Florida, USA.
  • Ritter A; Center for Advanced Research & Education, Gainesville, Georgia, USA.
  • Kelly SA; CytoDyn, Vancouver, Washington, USA.
  • Pourhassan NZ; CytoDyn, Vancouver, Washington, USA.
  • Tiwary M; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.
  • Sacha JB; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.
  • Hansen SG; Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA.
  • Recknor C; CytoDyn, Vancouver, Washington, USA.
  • Yang OO; Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at the University of California-Los Angeles, Los Angeles, California, USA.
Clin Infect Dis ; 75(7): 1232-1234, 2022 Sep 30.
Article in English | MEDLINE | ID: covidwho-1806304
ABSTRACT
In an exploratory trial treating "long COVID" with the CCR5-binding antibody leronlimab, we observed significantly increased blood cell surface CCR5 in treated symptomatic responders but not in nonresponders or placebo-treated participants. These findings suggest an unexpected mechanism of abnormal immune downmodulation in some persons that is normalized by leronlimab. Clinical Trials Registration. NCT04678830.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid