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COVID-19 vaccination status and testing rates in Finland-A potential cause for bias in observational vaccine effectiveness analysis.
Kuitunen, Ilari; Uimonen, Mikko; Seppälä, Santeri J; Ponkilainen, Ville T.
  • Kuitunen I; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
  • Uimonen M; Mikkeli Central Hospital, Mikkeli, Finland.
  • Seppälä SJ; Central Finland Hospital Nova, Jyväskylä, Finland.
  • Ponkilainen VT; Mikkeli Central Hospital, Mikkeli, Finland.
Influenza Other Respir Viruses ; 16(5): 842-845, 2022 09.
Article in English | MEDLINE | ID: covidwho-1807135
ABSTRACT
COVID-19 vaccination effectiveness has been monitored in observational studies (test-negativity design or traditional cohort design), but these studies have not addressed the potential behavioral bias between vaccinated and unvaccinated individuals. We aimed to address this by comparing COVID-19 testing rates between vaccination status and whether vaccination changes the testing rates. We found that three times vaccinated had least tests performed during the pandemic and unvaccinated had the highest testing rate. Each vaccination dose increased the testing rate. In conclusion the observational studies addressing vaccine effectiveness should also present testing rates between vaccinated and unvaccinated to address the potential behavioral bias.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Country/Region as subject: Europa Language: English Journal: Influenza Other Respir Viruses Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: Irv.12993

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Country/Region as subject: Europa Language: English Journal: Influenza Other Respir Viruses Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: Irv.12993