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Saliva as a diagnostic specimen for SARS-CoV-2 detection: A scoping review.
Wang, Yifei; Upadhyay, Akshaya; Pillai, Sangeeth; Khayambashi, Parisa; Tran, Simon D.
  • Wang Y; McGill University, Montreal, QC, Canada.
  • Upadhyay A; McGill University, Montreal, QC, Canada.
  • Pillai S; McGill University, Montreal, QC, Canada.
  • Khayambashi P; McGill University, Montreal, QC, Canada.
  • Tran SD; McGill University, Montreal, QC, Canada.
Oral Dis ; 28 Suppl 2: 2362-2390, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-1807238
ABSTRACT

OBJECTIVES:

This scoping review aims to summarize the diagnostic value of saliva assessed from current studies that (1) compare its performance in reverse transcriptase-polymerase chain reaction testing to nasopharyngeal swabs, (2) evaluate its performance in rapid and point-of-care COVID-19 diagnostic tests, and (3) explore its use as a specimen for detecting anti-SARS-CoV-2 antibodies. MATERIALS AND

METHODS:

A systematic search was performed on the following databases Medline and Embase (Ovid), World Health Organization, Centers for Disease Control and Prevention, and Global Health (Ovid) from January 2019 to September 2021. Of the 657 publications identified from the searches, n = 146 articles were included in the final scoping review.

RESULTS:

Our findings showcase that salivary samples exceed nasopharyngeal swabs in detecting SARS-CoV-2 using reverse transcriptase-polymerase chain reaction testing in several studies. A select number of rapid antigen and point-of-care tests from the literature were also identified capable of high detection rates using saliva. Moreover, anti-SARS-CoV-2 antibodies have been shown to be detectable in saliva through biochemical assays.

CONCLUSION:

We highlight the potential of saliva as an all-rounded specimen in detecting SARS-CoV-2. However, future large-scale clinical studies will be needed to support its widespread use as a non-invasive clinical specimen for COVID-19 testing.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Oral Dis Journal subject: Dentistry Year: 2022 Document Type: Article Affiliation country: Odi.14216

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Oral Dis Journal subject: Dentistry Year: 2022 Document Type: Article Affiliation country: Odi.14216