SARS-CoV-2 Evolution: On the Sudden Appearance of the Omicron Variant.
J Virol
; 96(7): e0009022, 2022 04 13.
Article
in English
| MEDLINE | ID: covidwho-1807317
ABSTRACT
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads rapidly and harbors many mutations in the spike protein, but the origin of this virus variant remains unclear. We address the role of unusual virus evolution mechanisms such as hypermutation, out-of-frame reading, and recombination. Rather, regular Darwinian evolution, that is, the repeated selection of beneficial spike mutations, seems to have led to the appearance of the grossly altered spike protein of the Omicron variant.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
Topics:
Variants
Limits:
Humans
Language:
English
Journal:
J Virol
Year:
2022
Document Type:
Article
Affiliation country:
Jvi.00090-22
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