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Occupation, work-related contact and SARS-CoV-2 anti-nucleocapsid serological status: findings from the Virus Watch prospective cohort study.
Beale, Sarah; Patel, Parth; Rodger, Alison; Braithwaite, Isobel; Byrne, Thomas; Fong, Wing Lam Erica; Fragaszy, Ellen; Geismar, Cyril; Kovar, Jana; Navaratnam, Annalan; Nguyen, Vincent; Shrotri, Madhumita; Aryee, Anna; Aldridge, Robert; Hayward, Andrew.
  • Beale S; UCL Institute of Epidemiology and Health Care, University College London, London, UK sarah.beale.19@ucl.ac.uk.
  • Patel P; UCL Institute of Health Informatics, University College London, London, UK.
  • Rodger A; UCL Institute of Health Informatics, University College London, London, UK.
  • Braithwaite I; Extreme Events and Health Protection Team, Centre for Radiation, Chemicals and Environmental Hazards, Public Health England, London, UK.
  • Byrne T; UCL Institute of Health Informatics, University College London, London, UK.
  • Fong WLE; UCL Institute of Health Informatics, University College London, London, UK.
  • Fragaszy E; UCL Institute of Health Informatics, University College London, London, UK.
  • Geismar C; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
  • Kovar J; UCL Institute of Health Informatics, University College London, London, UK.
  • Navaratnam A; UCL Institute of Epidemiology and Health Care, University College London, London, UK.
  • Nguyen V; UCL Institute of Health Informatics, University College London, London, UK.
  • Shrotri M; UCL Institute of Health Informatics, University College London, London, UK.
  • Aryee A; UCL Institute of Health Informatics, University College London, London, UK.
  • Aldridge R; UCL Institute of Health Informatics, University College London, London, UK.
  • Hayward A; UCL Institute of Health Informatics, University College London, London, UK.
Occup Environ Med ; 2022 Apr 21.
Article in English | MEDLINE | ID: covidwho-1807493
ABSTRACT

OBJECTIVES:

Risk of SARS-CoV-2 infection varies across occupations; however, investigation into factors underlying differential risk is limited. We aimed to estimate the total effect of occupation on SARS-CoV-2 serological status, whether this is mediated by workplace close contact, and how exposure to poorly ventilated workplaces varied across occupations.

METHODS:

We used data from a subcohort (n=3775) of adults in the UK-based Virus Watch cohort study who were tested for SARS-CoV-2 anti-nucleocapsid antibodies (indicating natural infection). We used logistic decomposition to investigate the relationship between occupation, contact and seropositivity, and logistic regression to investigate exposure to poorly ventilated workplaces.

RESULTS:

Seropositivity was 17.1% among workers with daily close contact vs 10.0% for those with no work-related close contact. Compared with other professional occupations, healthcare, indoor trade/process/plant, leisure/personal service, and transport/mobile machine workers had elevated adjusted total odds of seropositivity (1.80 (1.03 to 3.14) - 2.46 (1.82 to 3.33)). Work-related contact accounted for a variable part of increased odds across occupations (1.04 (1.01 to 1.08) - 1.23 (1.09 to 1.40)). Occupations with raised odds of infection after accounting for work-related contact also had greater exposure to poorly ventilated workplaces.

CONCLUSIONS:

Work-related close contact appears to contribute to occupational variation in seropositivity. Reducing contact in workplaces is an important COVID-19 control measure.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal subject: Occupational Medicine / Environmental Health Year: 2022 Document Type: Article Affiliation country: Oemed-2021-107920

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal subject: Occupational Medicine / Environmental Health Year: 2022 Document Type: Article Affiliation country: Oemed-2021-107920