PregTox: A Resource of Knowledge about Drug Fetal Toxicity.
Biomed Res Int
; 2022: 4284146, 2022.
Article
in English
| MEDLINE | ID: covidwho-1807688
ABSTRACT
Background:
It is of vital importance to determine the safety of drugs. Pregnant women, as a special group, need to evaluate the effects of drugs on pregnant women as well as the fetus. The use of drugs during pregnancy may be subject to fetal toxicity, thus affecting the development of the fetus or even leading to stillbirth. The U.S. Food and Drug Administration (FDA) issued a toxicity rating for drugs used during pregnancy in 1979. These toxicity ratings are denoted by the letters A, B, C, D, and X. However, the query of drug pregnancy category has yet to be well established as electronic service.Results:
Here, we presented PregTox, a publicly accessible resource for pregnancy category information of 1114 drugs. The PregTox database also included chemical structures, important physico-chemical properties, protein targets, and relevant signaling pathways. An advantage of the database is multiple search options which allow systematic analyses. In a case study, we demonstrated that a set of chemical descriptors could effectively discriminate high-risk drugs from others (area under ROC curve reached 0.81).Conclusions:
PregTox can serve as a unique drug safety data source for drug development and pharmacological research.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Drug-Related Side Effects and Adverse Reactions
Type of study:
Experimental Studies
/
Prognostic study
/
Systematic review/Meta Analysis
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Biomed Res Int
Year:
2022
Document Type:
Article
Affiliation country:
2022
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