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Inflammation in Cerebral Venous Thrombosis.
Ding, Jiayue; Song, Baoying; Xie, Xiran; Li, Xaingyu; Chen, Zhiying; Wang, Zhongao; Pan, Liqun; Lan, Duo; Meng, Ran.
  • Ding J; Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.
  • Song B; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Xie X; Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
  • Li X; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Chen Z; Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
  • Wang Z; Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
  • Pan L; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Lan D; Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
  • Meng R; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Front Immunol ; 13: 833490, 2022.
Article in English | MEDLINE | ID: covidwho-1809392
ABSTRACT
Cerebral venous thrombosis (CVT) is a rare form of cerebrovascular disease that impairs people's wellbeing and quality of life. Inflammation is considered to play an important role in CVT initiation and progression. Several studies have reported the important role of leukocytes, proinflammatory cytokines, and adherence molecules in the CVT-related inflammatory process. Moreover, inflammatory factors exacerbate CVT-induced brain tissue injury leading to poor prognosis. Based on clinical observations, emerging evidence shows that peripheral blood inflammatory biomarkers-especially neutrophil-to-lymphocyte ratio (NLR) and lymphocyte count-are correlated with CVT [mean difference (MD) (95%CI), 0.74 (0.11, 1.38), p = 0.02 and -0.29 (-0.51, -0.06), p = 0.01, respectively]. Moreover, increased NLR and systemic immune-inflammation index (SII) portend poor patient outcomes. Evidence accumulated since the outbreak of coronavirus disease-19 (COVID-19) indicates that COVID-19 infection and COVID-19 vaccine can induce CVT through inflammatory reactions. Given the poor understanding of the association between inflammation and CVT, many conundrums remain unsolved. Further investigations are needed to elucidate the exact relationship between inflammation and CVT in the future.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Venous Thrombosis / Intracranial Thrombosis / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.833490

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Venous Thrombosis / Intracranial Thrombosis / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.833490