Nanomaterial-Based Label-Free Electrochemical Aptasensors for the Detection of Thrombin.
Biosensors (Basel)
; 12(4)2022 Apr 16.
Article
in English
| MEDLINE | ID: covidwho-1809706
ABSTRACT
Thrombin plays a central role in hemostasis and its imbalances in coagulation can lead to various pathologies. It is of clinical significance to develop a fast and accurate method for the quantitative detection of thrombin. Electrochemical aptasensors have the capability of combining the specific selectivity from aptamers with the extraordinary sensitivity from electrochemical techniques and thus have attracted considerable attention for the trace-level detection of thrombin. Nanomaterials and nanostructures can further enhance the performance of thrombin aptasensors to achieve high sensitivity, selectivity, and antifouling functions. In highlighting these material merits and their impacts on sensor performance, this paper reviews the most recent advances in label-free electrochemical aptasensors for thrombin detection, with an emphasis on nanomaterials and nanostructures utilized in sensor design and fabrication. The performance, advantages, and limitations of those aptasensors are summarized and compared according to their material structures and compositions.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Biosensing Techniques
/
Nanostructures
/
Aptamers, Nucleotide
Type of study:
Diagnostic study
/
Prognostic study
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Bios12040253
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