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Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids.
DeFelice, Brian C; Fiehn, Oliver; Belafsky, Peter; Ditterich, Constanze; Moore, Michael; Abouyared, Marianne; Beliveau, Angela M; Farwell, D Gregory; Bewley, Arnaud F; Clayton, Shannon M; Archard, Joehleen A; Pavlic, Jordan; Rao, Shyam; Kuhn, Maggie; Deng, Peter; Halmai, Julian; Fink, Kyle D; Birkeland, Andrew C; Anderson, Johnathon D.
  • DeFelice BC; West Coast Metabolomics Center, University of California, Davis, CA 95616, USA.
  • Fiehn O; West Coast Metabolomics Center, University of California, Davis, CA 95616, USA.
  • Belafsky P; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
  • Ditterich C; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
  • Moore M; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
  • Abouyared M; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
  • Beliveau AM; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
  • Farwell DG; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
  • Bewley AF; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
  • Clayton SM; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
  • Archard JA; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
  • Pavlic J; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
  • Rao S; Department of Radiation Oncology, University of California, Davis, CA 95616, USA.
  • Kuhn M; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
  • Deng P; Department of Neurology, University of California, Davis, CA 95616, USA.
  • Halmai J; Department of Neurology, University of California, Davis, CA 95616, USA.
  • Fink KD; Department of Neurology, University of California, Davis, CA 95616, USA.
  • Birkeland AC; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
  • Anderson JD; Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, CA 95616, USA.
Diagnostics (Basel) ; 12(4)2022 Mar 24.
Article in English | MEDLINE | ID: covidwho-1809760
ABSTRACT

Background:

Novel, non-invasive diagnostic biomarkers that facilitate early intervention in head and neck cancer are urgently needed. Polyamine metabolites have been observed to be elevated in numerous cancer types and correlated with poor prognosis. The aim of this study was to assess the concentration of polyamines in the saliva and urine from head and neck cancer (HNC) patients, compared to healthy controls.

Methods:

Targeted metabolomic analysis was performed on saliva and urine from 39 HNC patient samples and compared to 89 healthy controls using a quantitative, targeted liquid chromatography mass spectrometry approach.

Results:

The metabolites N1-acetylspermine (ASP), N8-acetylspermidine (ASD) and N1,N12-diacetylspermine (DAS) were detected at significantly different concentrations in the urine of HNC patients as compared to healthy controls. Only ASP was detected at elevated levels in HNC saliva as compared to healthy controls.

Conclusion:

These data suggest that assessment of polyamine-based metabolite biomarkers within the saliva and urine warrants further investigation as a potential diagnostic in HNC patients.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Diagnostics12040797

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Diagnostics12040797