Problems of Red Blood Cell Aggregation and Deformation Assessed by Laser Tweezers, Diffuse Light Scattering and Laser Diffractometry
Photonics
; 9(4):238, 2022.
Article
in English
| ProQuest Central | ID: covidwho-1810086
ABSTRACT
This study aims to highlight the problems with implementing optical techniques (laser tweezers, diffuse light scattering and laser diffractometry) in clinical hemorheological practice. We provide the feasibility of these techniques to assess microrheological effects of various molecular mechanisms affecting RBC aggregation and deformability. In particular, we show that they allow assessment of changes in RBC aggregation in whole blood samples both on the level of single cells and on the level of large ensembles of cells. Application of these methods allows for studying the mechanisms of RBC aggregation because they are sensitive to changes in the medium which surrounds the RBC (i.e., blood plasma, serum or model solutions of blood plasma proteins) and to changes in the cellular properties of RBCs (i.e., effects on the cell membrane due to glycoprotein inhibition).
Physics--Optics; RBC aggregation and deformation; laser tweezers; diffuse light scattering; diffractometry; Erythrocytes; Light scattering; Formability; Blood; Plasma; Lasers; Blood vessels; Severe acute respiratory syndrome coronavirus 2; Deformability; Molecular modelling; Deformation effects; Blood platelets; Agglomeration; Hematology; Red blood cells; Cell aggregation; Rheology; Cell membranes; Plasma proteins; Blood plasma; Optics; Deformation; Glycoproteins; Shear stress
Full text:
Available
Collection:
Databases of international organizations
Database:
ProQuest Central
Language:
English
Journal:
Photonics
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS