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Humoral Immune Response Induced by the BBIBP-CorV Vaccine (Sinopharm) in Healthcare Workers: A Cohort Study.
Gómez de la Torre, Juan C; Cáceres-DelAguila, José Alonso; Muro-Rojo, Cecilia; De La Cruz-Escurra, Nathalia; Copaja-Corzo, Cesar; Hueda-Zavaleta, Miguel; Arenas Siles, Daniella; Benites-Zapata, Vicente A.
  • Gómez de la Torre JC; Clinical Laboratory Roe, Lima 15076, Peru.
  • Cáceres-DelAguila JA; Clinical Laboratory Roe, Lima 15076, Peru.
  • Muro-Rojo C; Clinical Laboratory Roe, Lima 15076, Peru.
  • De La Cruz-Escurra N; Clinical Laboratory Roe, Lima 15076, Peru.
  • Copaja-Corzo C; Faculty of Health Sciences, Universidad Privada de Tacna, Tacna 23003, Peru.
  • Hueda-Zavaleta M; Faculty of Health Sciences, Universidad Privada de Tacna, Tacna 23003, Peru.
  • Arenas Siles D; Hospital III Daniel Alcides Carrión-Essalud Tacna, Tacna 23000, Peru.
  • Benites-Zapata VA; Faculty of Medicine, Scientific University of the South, Lima 15067, Peru.
Trop Med Infect Dis ; 7(5)2022 Apr 24.
Article in English | MEDLINE | ID: covidwho-1847406
ABSTRACT
Insufficient data have been reported about the effect of the inactivated SARS-CoV-2 vaccine (BBIBP-CorV) on the humoral response through time in healthcare workers (HCW). This retrospective cohort studied the information of 252 HCW from a private laboratory, comparing the antibody-mediated response provoked by BBIBP-CorV between HCW previously infected with SARS-CoV-2 (PI) and not previously infected (NPI), employing the Elecsys® anti-SARS-CoV-2 S and the cPass™ SARS-CoV-2 Neutralization Antibody Detection kit at intervals of 21, 90, and 180 days after vaccination. The presence of neutralizing antibodies in HCW 21 days after full vaccination was 100% in PI and 91.60% in NPI. We observed a progressive decrease in antibody levels over time in both groups. Comparing HCW PI with NPI, PI had a 10.9, 14.3, and 8.6-fold higher antibody titer with the Elecsys® anti-SARS-CoV-2 S at 21 (p < 0.001), 90 (p< 0.001) and 180 days (p <0.001) respectively, compared to NPI. Using the percent of signal inhibition (PSI) of the antibody neutralization cPass™, HCW PI showed a level of 1.3, 2.0, and 3.1 times more antibodies, at 21 (p <0.001), 90 (p <0.001), and 180 days (p <0.001) respectively, compared to NPI. We determined a progressive decrease in humoral immunity over time, particularly higher in those NPI.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Randomized controlled trials Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Tropicalmed7050066

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Randomized controlled trials Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Tropicalmed7050066