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Challenges in the Development of Drugs for Sarcopenia and Frailty - Report from the International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force.
Cesari, M; Bernabei, R; Vellas, B; Fielding, R A; Rooks, D; Azzolino, D; Mariani, J; Oliva, A A; Bhasin, S; Rolland, Y.
  • Cesari M; Prof. Matteo Cesari; Geriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri; Via Camaldoli 64, 20138 Milano, Italy; Twitter: @macesari; E-mail: macesari@gmail.com.
J Frailty Aging ; 11(2): 135-142, 2022.
Article in English | MEDLINE | ID: covidwho-1811434
ABSTRACT
Sarcopenia and frailty represent two burdensome conditions, contributing to a broad spectrum of adverse outcomes. The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force met virtually in September 2021 to discuss the challenges in the development of drugs for sarcopenia and frailty. Lifestyle interventions are the current mainstay of treatment options in the prevention and management of both conditions. However, pharmacological agents are needed for people who do not respond to lifestyle modifications, for those who are unable to adhere, or for whom such interventions are inaccessible/unfeasible. Preliminary results of ongoing trials were presented and discussed. Several pharmacological candidates are currently under clinical evaluation with promising early results, but none have been approved for either frailty or sarcopenia. The COVID-19 pandemic has reshaped how clinical trials are conducted, in particular by enhancing the usefulness of remote technologies and assessments/interventions.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sarcopenia / Frailty / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: J Frailty Aging Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sarcopenia / Frailty / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: J Frailty Aging Year: 2022 Document Type: Article