Toll-like receptors matter: plasmacytoid dendritic cells in COVID-19.
EMBO J
; 41(10): e111208, 2022 05 16.
Article
in English
| MEDLINE | ID: covidwho-1811580
ABSTRACT
Plasmacytoid dendritic cells (pDC) have the unique ability to rapidly mount high-level antiviral type I interferon (IFN-I) responses during diverse virus infections. In COVID-19 patients, reduced pDC numbers correlate with diminished IFN-I serum levels and enhanced disease severity. However, the molecular mechanisms underlying SARS-CoV-2-mediated pDC stimulation to induce cytokine responses are still largely unclear. In this issue of the EMBO Journal, van der Sluis and colleagues tackled this question by using an innovative hematopoietic stem and progenitor cells (HSPC)-pDC system that allows gene editing and the detailed analysis of pDC sensing mechanisms.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Interferon Type I
/
Toll-Like Receptors
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
EMBO J
Year:
2022
Document Type:
Article
Affiliation country:
Embj.2022111208
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