Effect of favipiravir and standard COVID-19 therapy on amino transferase in a sample of Iraqi COVID-19 patients
Natural Volatiles & Essential Oils
; 8(4):14093-14104, 2021.
Article
in English
| GIM | ID: covidwho-1812880
ABSTRACT
Background:
COVID-19 is a condition that can proceed in a broad spectrum from asymptomatic moderate sickness to severe lung disease. Hepatic harm in COVID-19 may arise owing to the direct cytopathic action of the virus, uncontrolled immunological response, hypoxia related to pneumonia, and the medications used in therapy. In the literature, the rate of rise in blood transaminase levels of patients hospitalized with COVID-19 was determined to be 37.5%. Also, rise in serum transaminase levels in COVID-19 patients has been shown to be related with higher mortality in the literature. Favipiravir is a ribonucleic acid (RNA)-dependent RNA polymerase (RdRP) inhibitor antiviral drug used in the treatment of coronavirus disease-2019 (COVID-19)Aims:
In this study, we investigated the changes in serum transaminase levels of patients who were hospitalized with the diagnosis of COVID-19 and underwent favipiravir therapy. Materials andmethods:
case-control research was done. It was done in a multi-hospital of Baghdad city over the period from November 1, 2020, to August 1, 2021. All patients in this study were hospitalized patients with polymerase chain reaction identified Coronavirus illness 2019 (severe cases) according to Iraqi criteria and supervision of a professional.
human diseases; coronavirus disease 2019; viral diseases; patients; mortality; pandemics; drug therapy; aminotransferases; antiviral agents; case-control studies; case studies; diagnosis; hospitals; hypoxia; immune response; lungs; oxygen deficiency; pneumonia; respiratory diseases; man; Severe acute respiratory syndrome coronavirus 2; Iraq; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; medium Human Development Index countries; Middle East; upper-middle income countries; West Asia; Asia; SARS-CoV-2; viral infections; death rate; chemotherapy; transaminases; antivirals; immunity reactions; immunological reactions; lung diseases
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Collection:
Databases of international organizations
Database:
GIM
Type of study:
Experimental Studies
Language:
English
Journal:
Natural Volatiles & Essential Oils
Year:
2021
Document Type:
Article
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