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Periodontitis-Derived Dark-NETs in Severe Covid-19.
Vitkov, Ljubomir; Knopf, Jasmin; Krunic, Jelena; Schauer, Christine; Schoen, Janina; Minnich, Bernd; Hannig, Matthias; Herrmann, Martin.
  • Vitkov L; Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University, Homburg, Germany.
  • Knopf J; Department of Environment & Biodiversity, University of Salzburg, Salzburg, Austria.
  • Krunic J; Department of Dental Pathology, University of East Sarajevo, East Sarajevo, Bosnia and Herzegovina.
  • Schauer C; Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Schoen J; Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Minnich B; Department of Dental Pathology, University of East Sarajevo, East Sarajevo, Bosnia and Herzegovina.
  • Hannig M; Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Herrmann M; Deutsches Zentrum für Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Front Immunol ; 13: 872695, 2022.
Article in English | MEDLINE | ID: covidwho-1952330
ABSTRACT
The frequent severe COVID-19 course in patients with periodontitis suggests a link of the aetiopathogenesis of both diseases. The formation of intravascular neutrophil extracellular traps (NETs) is crucial to the pathogenesis of severe COVID-19. Periodontitis is characterised by an increased level of circulating NETs, a propensity for increased NET formation, delayed NET clearance and low-grade endotoxemia (LGE). The latter has an enormous impact on innate immunity and susceptibility to infection with SARS-CoV-2. LPS binds the SARS-CoV-2 spike protein and this complex, which is more active than unbound LPS, precipitates massive NET formation. Thus, circulating NET formation is the common denominator in both COVID-19 and periodontitis and other diseases with low-grade endotoxemia like diabetes, obesity and cardiovascular diseases (CVD) also increase the risk to develop severe COVID-19. Here we discuss the role of propensity for increased NET formation, DNase I deficiency and low-grade endotoxaemia in periodontitis as aggravating factors for the severe course of COVID-19 and possible strategies for the diminution of increased levels of circulating periodontitis-derived NETs in COVID-19 with periodontitis comorbidity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Periodontitis / Endotoxemia / Extracellular Traps / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.872695

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Periodontitis / Endotoxemia / Extracellular Traps / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.872695