The emerging roles of retromer and sorting nexins in the life cycle of viruses.
Virol Sin
; 37(3): 321-330, 2022 Jun.
Article
in English
| MEDLINE | ID: covidwho-1813214
ABSTRACT
Retromer and sorting nexins (SNXs) transport cargoes from endosomes to the trans-Golgi network or plasma membrane. Recent studies have unveiled the emerging roles for retromer and SNXs in the life cycle of viruses, including members of Coronaviridae, Flaviviridae and Retroviridae. Key components of retromer/SNXs, such as Vps35, Vps26, SNX5 and SNX27, can affect multiple steps of the viral life cycle, including facilitating the entry of viruses into cells, participating in viral replication, and promoting the assembly of virions. Here we present a comprehensive updated review on the interplay between retromer/SNXs and virus, which will shed mechanistic insights into controlling virus infection.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Viruses
/
Sorting Nexins
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Virol Sin
Journal subject:
Virology
Year:
2022
Document Type:
Article
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