Respiratory virus detection in the upper respiratory tract of asymptomatic, community-dwelling older people.
BMC Infect Dis
; 22(1): 411, 2022 Apr 28.
Article
in English
| MEDLINE | ID: covidwho-1813294
ABSTRACT
BACKGROUND:
The prevalence of virus positivity in the upper respiratory tract of asymptomatic community-dwelling older people remains elusive. Our objective was to investigate the prevalence of respiratory virus PCR positivity in asymptomatic community-dwelling older people using saliva samples and nasopharyngeal and oropharyngeal swabs.METHODS:
We analyzed 504 community-dwelling adults aged ≥ 65 years who were ambulatory and enrolled in a cross-sectional study conducted from February to December 2018 in Nagasaki city, Japan. Fourteen respiratory viruses were identified in saliva, nasopharyngeal and oropharyngeal samples using multiplex PCR assays.RESULTS:
The prevalences of PCR positivity for rhinovirus, influenza A, enterovirus and any respiratory virus were 12.9% (95% CI 10.1-16.1%), 7.1% (95% CI 5.1-9.8%), 6.9% (95% CI 4.9-9.5%) and 25.2% (95% CI 21.5-29.2%), respectively. Rhinovirus was detected in 21.5% of subjects, influenza A in 38.9% of subjects, enterovirus in 51.4% of subjects and any virus in 32.3% of subjects using only saliva sampling.CONCLUSIONS:
The prevalences of several respiratory viruses were higher than the percentages reported previously in pharyngeal samples from younger adults. Saliva sampling is a potentially useful method for respiratory virus detection in asymptomatic populations.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Tract Infections
/
Viruses
/
Enterovirus Infections
/
Influenza, Human
Type of study:
Diagnostic study
/
Observational study
/
Randomized controlled trials
Limits:
Adult
/
Aged
/
Humans
Language:
English
Journal:
BMC Infect Dis
Journal subject:
Communicable Diseases
Year:
2022
Document Type:
Article
Affiliation country:
S12879-022-07355-W
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