Herbal inhibitors of SARS-CoV-2 Mpro effectively ameliorate acute lung injury in mice.
IUBMB Life
; 74(6): 532-542, 2022 06.
Article
in English
| MEDLINE | ID: covidwho-1813517
ABSTRACT
Coronavirus disease 2019, a newly emerging serious infectious disease, has spread worldwide. To date, effective drugs against the disease are limited. Traditional Chinese medicine was commonly used in treating COVID-19 patients in China. Here we tried to identify herbal effective lipid compounds from the lipid library of 92 heat-clearing and detoxication Chinese herbs. Through virtual screening, enzymatic activity and inhibition assays, and surface plasmon resonance tests, we identified lipid compounds targeting the main protease (Mpro ) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and verified their functions. Here, we found that natural lipid compounds LPC (140/00) and LPC (160/00) could target SARS-CoV-2 Mpro , recover cell death induced by SARS-CoV-2, and ameliorate acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) induced by bacterial lipopolysaccharides and virus poly (IC) mimics in vivo and in vitro. Our results suggest that LPC (140/00) and LPC (160/00) might be potential pan remedy against ARDS.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome
/
Acute Lung Injury
/
COVID-19 Drug Treatment
Type of study:
Experimental Studies
Topics:
Traditional medicine
Limits:
Animals
/
Humans
Language:
English
Journal:
IUBMB Life
Journal subject:
Molecular Biology
/
Biochemistry
Year:
2022
Document Type:
Article
Affiliation country:
Iub.2616
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