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Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review.
Almas, Talal; Rehman, Sarah; Mansour, Eyad; Khedro, Tarek; Alansari, Ali; Malik, Jahanzeb; Alshareef, Norah; Nagarajan, Vikneswaran Raj; Al-Awaid, Abdulla Hussain; Alsufyani, Reema; Alsufyani, Majid; Rifai, Ali; Alzahrani, Ahlam; Nagarajan, Dhineswaran Raj; Abdullatif, Tala; Gunasaegaram, Varman; Alzadjali, Enaam; Subramanian, Arthi; Rahman, Abida; Sattar, Yasar; Galo, Jason; Virk, Hafeez Ul Hassan; Alraies, M Chadi.
  • Almas T; Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: talalalmas.almas@gmail.com.
  • Rehman S; Aga Khan University, Karachi, Pakistan.
  • Mansour E; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Khedro T; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Alansari A; University Hospital, National University of Ireland Galway, Galway, Ireland.
  • Malik J; Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan.
  • Alshareef N; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Nagarajan VR; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Al-Awaid AH; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Alsufyani R; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Alsufyani M; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Rifai A; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Alzahrani A; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Nagarajan DR; Sunway University School of Medicine and Health Science, Malaysia.
  • Abdullatif T; National University of Ireland, Galway, Ireland.
  • Gunasaegaram V; Galway University Hospital, Galway, Ireland.
  • Alzadjali E; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Subramanian A; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Rahman A; Trinity Centre for Global Health, Trinity College Dublin, Ireland.
  • Sattar Y; Department of Cardiology, West Virginia University, Morgantown, WV, USA.
  • Galo J; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
  • Virk HUH; Adena Regional Medical Center, Chillicothe, OH, USA.
  • Alraies MC; Department of Interventional Cardiology, Detroit Medical Center, DMC Heart Hospital, Detroit, MI, USA.
Biomed Pharmacother ; 149: 112843, 2022 May.
Article in English | MEDLINE | ID: covidwho-1814158
ABSTRACT
The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccination has significantly reduced disease-related hospitalizations and mortality. Nevertheless, many side-effects are being reported after COVID-19 vaccinations and myocarditis is the most commonly reported sequelae post vaccination. Majority of these diseases are associated with COVID-19 mRNA vaccines. Various studies have established a temporal relationship between these complications, yet the causality and the underlying pathogenesis remain hypothetical. In this review, we aim to critically appraise the available literature regarding the cardiovascular side effects of the various mRNA vaccines and the associated pathophysiology.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Biomed Pharmacother Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Biomed Pharmacother Year: 2022 Document Type: Article