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Mind the feline coronavirus: Comparison with SARS-CoV-2.
Gao, Yong-Yu; Liang, Xiang-Yu; Wang, Qian; Zhang, Shuang; Zhao, Han; Wang, Kai; Hu, Gui-Xue; Liu, William J; Gao, Feng-Shan.
  • Gao YY; College of Animal Medicine, Jilin Agricultural University, Changchun 130118, China.
  • Liang XY; College of Animal Medicine, Jilin Agricultural University, Changchun 130118, China.
  • Wang Q; Affiliated Hospital, Changchun University of Chinese Medicine, Changchun 130117, China.
  • Zhang S; College of Animal Medicine, Jilin Agricultural University, Changchun 130118, China.
  • Zhao H; College of Animal Medicine, Jilin Agricultural University, Changchun 130118, China.
  • Wang K; College of Animal Medicine, Jilin Agricultural University, Changchun 130118, China. Electronic address: wk197811@126.com.
  • Hu GX; College of Animal Medicine, Jilin Agricultural University, Changchun 130118, China. Electronic address: huguixue901103@163.com.
  • Liu WJ; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
  • Gao FS; College of Life Science and Technology, Dalian University, Dalian 116622, China. Electronic address: gfsh0626@126.com.
Gene ; 825: 146443, 2022 May 30.
Article in English | MEDLINE | ID: covidwho-1814426
ABSTRACT
Both feline coronavirus (FCoV) and SARS-CoV-2 are coronaviruses that infect cats and humans, respectively. However, cats have been shown to be susceptible to SARS-CoV-2, and FCoV also had been shown to infect human. To elucidate the relationship between FCoV and SARS-CoV-2, we highlight the main characteristics of the genome, the receptor usage, and the correlation of the receptor-binding domain (RBD) of spike proteins in FCoV and SARS-CoV-2. It is demonstrated that FCoV and SARS-CoV-2 are closely related to the main characteristics of the genome, receptor usage, and RBD of spike proteins with similar furin cleavage sites. In particular, the affinity of the conserved feline angiotensin-converting enzyme 2 (fACE2) receptor to the RBD of SARS-CoV-2 suggests that cats are susceptible to SARS-CoV-2. In addition, cross-species of coronaviruses between cats and humans or other domesticated animals are also discussed. This review sheds light on cats as potential intermediate hosts for SARS-CoV-2 transmission, and cross-species transmission or zoonotic infection of FCoV and SARS-CoV-2 between cats and humans was identified.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus, Feline / COVID-19 Type of study: Randomized controlled trials Limits: Animals Language: English Journal: Gene Year: 2022 Document Type: Article Affiliation country: J.gene.2022.146443

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus, Feline / COVID-19 Type of study: Randomized controlled trials Limits: Animals Language: English Journal: Gene Year: 2022 Document Type: Article Affiliation country: J.gene.2022.146443