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Inhibitory effect of honokiol on furin-like activity and SARS-CoV-2 infection.
Tanikawa, Takashi; Hayashi, Tsuyoshi; Suzuki, Ryuichiro; Kitamura, Masashi; Inoue, Yutaka.
  • Tanikawa T; Laboratory of Nutri-Pharmacotherapeutics Management, School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan.
  • Hayashi T; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
  • Suzuki R; Laboratory of Natural Products & Phytochemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan.
  • Kitamura M; Laboratory of Pharmacognocy, School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan.
  • Inoue Y; Laboratory of Nutri-Pharmacotherapeutics Management, School of Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Saitama, Japan.
J Tradit Complement Med ; 12(1): 69-72, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1814845
ABSTRACT
The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a pandemic and has caused damage to the lives of the people and economy of countries. However, the therapeutic reagents against SARS-CoV-2 remain unclear. The spike (S) protein of SARS-CoV-2 contains a cleavage motif at the S1/S2 boundary, known to be cleaved by furin. As cleavage is essential for S protein activation and viral entry, furin was selected as the target compound. In this study, we examined the inhibitory effects of two lignans (honokiol and magnolol) on furin-like enzymatic activity using a fluorogenic substrate with whole-cell lysates. Of two compounds tested, honokiol partially inhibited furin-like enzymatic activity. We further examined the anti-SARS-CoV-2 activity of honokiol using VeroE6 cell line, which is stably expressing a transmembrane protease serine 2 (TMPRSS2). It was shown that honokiol exhibited remarkable inhibition of SARS-CoV-2 infection. Therefore, honokiol and crude drugs which contain honokiol such as Magnolia species have a potential therapeutic reagents for SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Language: English Journal: J Tradit Complement Med Year: 2022 Document Type: Article Affiliation country: J.jtcme.2021.09.005

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Language: English Journal: J Tradit Complement Med Year: 2022 Document Type: Article Affiliation country: J.jtcme.2021.09.005