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Rapid synchronous type 1 IFN and virus-specific T cell responses characterize first wave non-severe SARS-CoV-2 infections.
Chandran, Aneesh; Rosenheim, Joshua; Nageswaran, Gayathri; Swadling, Leo; Pollara, Gabriele; Gupta, Rishi K; Burton, Alice R; Guerra-Assunção, José Afonso; Woolston, Annemarie; Ronel, Tahel; Pade, Corinna; Gibbons, Joseph M; Sanz-Magallon Duque De Estrada, Blanca; Robert de Massy, Marc; Whelan, Matthew; Semper, Amanda; Brooks, Tim; Altmann, Daniel M; Boyton, Rosemary J; McKnight, Áine; Captur, Gabriella; Manisty, Charlotte; Treibel, Thomas Alexander; Moon, James C; Tomlinson, Gillian S; Maini, Mala K; Chain, Benjamin M; Noursadeghi, Mahdad.
  • Chandran A; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  • Rosenheim J; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  • Nageswaran G; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  • Swadling L; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  • Pollara G; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  • Gupta RK; Institute for Global Health, University College London, London WC1E 6BT, UK.
  • Burton AR; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  • Guerra-Assunção JA; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  • Woolston A; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  • Ronel T; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  • Pade C; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
  • Gibbons JM; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
  • Sanz-Magallon Duque De Estrada B; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  • Robert de Massy M; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  • Whelan M; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  • Semper A; National Infection Service, Public Health England, Porton Down, Salisbury SP4 0JQ, UK.
  • Brooks T; National Infection Service, Public Health England, Porton Down, Salisbury SP4 0JQ, UK.
  • Altmann DM; Department of Immunology and Inflammation, Imperial College London, London SW7 2BX, UK.
  • Boyton RJ; Department of Infectious Disease, Imperial College London, London SW7 2BX, UK.
  • McKnight Á; Lung Division, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Captur G; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK.
  • Manisty C; Institute of Cardiovascular Sciences, University College London, London WC1E 6BT, UK.
  • Treibel TA; MRC Unit for Lifelong Health and Ageing, University College London, London WC1E 6BT, UK.
  • Moon JC; Institute of Cardiovascular Sciences, University College London, London WC1E 6BT, UK.
  • Tomlinson GS; Institute of Cardiovascular Sciences, University College London, London WC1E 6BT, UK.
  • Maini MK; Institute of Cardiovascular Sciences, University College London, London WC1E 6BT, UK.
  • Chain BM; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
  • Noursadeghi M; Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
Cell Rep Med ; 3(3): 100557, 2022 03 15.
Article in English | MEDLINE | ID: covidwho-1815271
ABSTRACT
Effective control of SARS-CoV-2 infection on primary exposure may reveal correlates of protective immunity to future variants, but we lack insights into immune responses before or at the time virus is first detected. We use blood transcriptomics, multiparameter flow cytometry, and T cell receptor (TCR) sequencing spanning the time of incident non-severe infection in unvaccinated virus-naive individuals to identify rapid type 1 interferon (IFN) responses common to other acute respiratory viruses and cell proliferation responses that discriminate SARS-CoV-2 from other viruses. These peak by the time the virus is first detected and sometimes precede virus detection. Cell proliferation is most evident in CD8 T cells and associated with specific expansion of SARS-CoV-2-reactive TCRs, in contrast to virus-specific antibodies, which lag by 1-2 weeks. Our data support a protective role for early type 1 IFN and CD8 T cell responses, with implications for development of universal T cell vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Cell Rep Med Year: 2022 Document Type: Article Affiliation country: J.xcrm.2022.100557

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Cell Rep Med Year: 2022 Document Type: Article Affiliation country: J.xcrm.2022.100557