Integrated analysis of transcriptomic data reveals the platelet response in COVID-19 disease.
Sci Rep
; 12(1): 6851, 2022 04 27.
Article
in English
| MEDLINE | ID: covidwho-1815595
ABSTRACT
COVID-19 is associated with an increased risk of thrombotic events. However, the pathogenesis of these complications is unclear and reports on platelet infection and activation by the virus are conflicting. Here, we integrated single-cell transcriptomic data to elucidate whether platelet activation is a specific response to SARS-CoV-2 infection or a consequence of a generalized inflammatory state. Although platelets from patients infected with SARS-CoV-2 over expressed genes involved in activation and aggregation when compared to healthy controls; those differences disappeared when the comparison was made with patients with generalized inflammatory conditions of other etiology than COVID-19. The membrane receptor for the virus, ACE-2, was not expressed by infected or control platelets. Our results suggest that platelet activation in patients with severe COVID-19 is mainly a consequence of a systemic inflammatory state than direct invasion and activation.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Blood Platelets
/
COVID-19
Type of study:
Etiology study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Sci Rep
Year:
2022
Document Type:
Article
Affiliation country:
S41598-022-10516-1
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