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Clinical Characteristics of COVID-19 Patients' Postvaccination.
Zhang, Xiao-Bin; Yang, Si-Jiu; Lin, Yong; Chen, Li-Li; Zhuang, Ya-Li; Zeng, Hui-Qing.
  • Zhang XB; Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
  • Yang SJ; Teaching Hospital of Fujian Medical University, Xiamen, China.
  • Lin Y; Teaching Hospital of Fujian Medical University, Xiamen, China.
  • Chen LL; Department of Intensive Care Unit, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
  • Zhuang YL; Department of Pulmonary and Critical Care Medicine, Xiamen Haicang Hospital, Xiamen, China.
  • Zeng HQ; Teaching Hospital of Fujian Medical University, Xiamen, China.
Viral Immunol ; 35(3): 236-243, 2022 04.
Article in English | MEDLINE | ID: covidwho-1815959
ABSTRACT
To investigate the clinical characteristic of domestic coronavirus disease 2019 (COVID-19) patients after vaccination campaign conducted in China. According to vaccination status and months from first vaccine dose to infection detection, patients were divided into unvaccinated, <3 months, 3-6 months, and >6 months groups. The information of demographic and clinical characteristics, laboratory and thoracic computed tomography (CT) findings, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid and IgM, IgG antibodies was retrospectively collected. Therapeutic approaches, temperature-normalizing and viral shedding times, outcomes were also summarized. SARS-CoV-2 antibody levels were further analyzed based on the other following variables time from second vaccine dose to infection, vaccine dose, the interval from the first to the second dose, and vaccine brand. Among 208 COVID-19 patients, 13 (6.28%) were unvaccinated. No significant differences in demographic and clinical characteristics, laboratory and CT findings, and SARS-CoV-2 nucleic acid loads were detected between groups (all p > 0.05). In comparison with the unvaccinated group, the median SARS-CoV-2 IgG levels were noticeably increased in those vaccinated groups (0.603 in unvaccinated, 15.925 in <3 months, 14.04 in 3-6 months, and 4.94 in >6 months, respectively, p < 0.05). However, SARS-CoV-2 IgG levels were not altered between groups divided based on the other variables. Vaccination does not affect the clinical characteristics in COVID-19 patients. COVID-19 patients with vaccination have high SARS-CoV-2 IgG levels. Underscore the necessity of rapid implementation of vaccination campaigns can be speculated.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nucleic Acids / COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Viral Immunol Journal subject: Allergy and Immunology / Virology Year: 2022 Document Type: Article Affiliation country: Vim.2021.0204

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nucleic Acids / COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Viral Immunol Journal subject: Allergy and Immunology / Virology Year: 2022 Document Type: Article Affiliation country: Vim.2021.0204