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False Coronavirus Disease 2019 Cases due to Contamination by Inactivated Virus Vaccine.
To, Kelvin Kai-Wang; Li, Xin; Lung, David Christopher; Ip, Jonathan Daniel; Chan, Wan-Mui; Chu, Allen Wing-Ho; Yip, Cyril Chik-Yan; Chen, Jonathan H K; Poon, Rosana Wing-Shan; Tsoi, Hoi-Wah; Lai, Raymond Wai-Man; To, Wing-Kin; Ren, Lili; Li, Mingkun; Cao, Yunlong; Xie, Xiaoliang Sunney; Jin, Dong-Yan; Yuen, Kwok-Yung.
  • To KK; State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
  • Li X; Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China.
  • Lung DC; State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
  • Ip JD; Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China.
  • Chan WM; Department of Pathology, Queen Elizabeth Hospital/Hong Kong Children's Hospital, Hong Kong Special Administrative Region, People's Republic of China.
  • Chu AW; State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
  • Yip CC; State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
  • Chen JHK; State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
  • Poon RW; Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China.
  • Tsoi HW; Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China.
  • Lai RW; Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China.
  • To WK; State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China.
  • Ren L; Department of Microbiology, Prince of Wales Hospital, Hong Kong Special Administrative Region, People's Republic of China.
  • Li M; Department of Pathology, Princess Margaret Hospital, Hong Kong Special Administrative Region, People's Republic of China.
  • Cao Y; National Health Commission Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
  • Xie XS; Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
  • Jin DY; Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, People's Republic of China.
  • Yuen KY; University of Chinese Academy of Sciences, Beijing, People's Republic of China.
Clin Infect Dis ; 74(8): 1485-1488, 2022 04 28.
Article in English | MEDLINE | ID: covidwho-1816023
ABSTRACT
A false-positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse-transcription polymerase chain reaction result can lead to unnecessary public health measures. We report 2 individuals whose respiratory specimens were contaminated by an inactivated SARS-CoV-2 vaccine strain (CoronaVac), likely at vaccination premises. Incidentally, whole genome sequencing of CoronaVac showed adaptive deletions on the spike protein, which do not result in observable changes of antigenicity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article