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Anti-spike IgG antibody kinetics following the second and third doses of BNT162b2 vaccine in nursing home residents.
Jeulin, Helene; Labat, Carlos; Duarte, Kevin; Toupance, Simon; Nadin, Gregoire; Craus, Denis; Georgiopoulos, Ioannis; Gantois, Isabelle; Goehringer, François; Benetos, Athanase.
  • Jeulin H; Université de Lorraine, CNRS, LCPME, Nancy, France.
  • Labat C; Université de Lorraine, CHRU-Nancy Brabois, Departement of Virology, Vandœuvre-lès-Nancy, France.
  • Duarte K; Université de Lorraine, INSERM, DCAC, Vandœuvre-lès-Nancy, France.
  • Toupance S; Université de Lorraine, INSERM, CHRU-Nancy Brabois, Centre d'Investigation Clinique Pluridisciplinaire (CIC-P) 14-33, Vandœuvre-lès-Nancy, France.
  • Nadin G; Université de Lorraine, INSERM, DCAC, Vandœuvre-lès-Nancy, France.
  • Craus D; Sorbonne Université, CNRS, LJLL, Paris, France.
  • Georgiopoulos I; Maison Médicale, Rosières-aux-Salines, France.
  • Gantois I; Université de Lorraine, CHRU-Nancy Brabois, Department of Clinical Geriatrics, Vandœuvre-lès-Nancy, France.
  • Goehringer F; Université de Lorraine, CHRU-Nancy Brabois, Department of Clinical Geriatrics, Vandœuvre-lès-Nancy, France.
  • Benetos A; Université de Lorraine, CHRU-Nancy Brabois, Department of Infectious and Tropical Diseases, Vandœuvre-lès-Nancy, France.
J Am Geriatr Soc ; 70(9): 2552-2560, 2022 09.
Article in English | MEDLINE | ID: covidwho-1816591
ABSTRACT

BACKGROUND:

Duration of post-vaccination protection against COVID-19 in nursing home (NH) residents is a critical issue. The objective of this study was to estimate the duration of the IgG(S) response to the mRNA BNT162b2 vaccine in NH residents with (COV-Yes) or without (COV-No) history of SARS-CoV-2 infection.

METHODS:

A 574 COV-Yes and COV-No NH residents were included in 2 cohorts Main (n = 115, median age 87 years) or Confirmatory (n = 459, median age 89 years). IgG(S) quantification was carried out at three different time points following the BNT162b2 vaccine three (1st) and seven (2nd) months after the 2nd dose, and 1 month after the 3rd dose (3rd quantification) in the Main cohort, and twice (2nd and 3rd) in the Confirmatory cohort. The seroneutralization capacity according to COVID-19 history was also measured in a subgroup of patients.

RESULTS:

Neutralization capacity was strongly correlated with IgG(S) levels (R276%) without any difference between COV-Yes and COV-No groups for the same levels of IgG(S). After the 2nd dose, duration of the assumed robust protection (IgG(S) >264 BAU/ml) was two-fold higher in the COV-Yes vs. COV-No group 12.60 (10.69-14.44) versus 5.76 (3.91-8.64) months, with this advantage mainly due to the higher IgG(S) titers after the 2nd dose and secondary to a slower decay over time. After the 3rd dose, duration of robust protection was estimated at 11.87 (9.88-14.87) (COV-Yes) and 8.95 (6.85-11.04) (COV-No) months. These results were similar in both cohorts. CONCLUSIONS AND RELEVANCE In old subjects living in NH, history of SARS-CoV-2 infection provides a clear advantage in the magnitude and duration of high IgG(S) titers following the 2nd dose. Importantly, the 3rd dose induces a much more pronounced IgG(S) response than the 2nd dose in COV-No subjects, the effect of which should be able to ensure a prolonged protection against severe forms of COVID-19 in these subjects.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: J Am Geriatr Soc Year: 2022 Document Type: Article Affiliation country: Jgs.17837

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: J Am Geriatr Soc Year: 2022 Document Type: Article Affiliation country: Jgs.17837