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Acquired long QT syndrome due to antiemetics, COVID-19 and Blastocystis hominis induced exacerbation of congenital chloride losing diarrhoea.
Rajendram, Rajkumar; Alghamdi, Ahmed Abdullah; Alanazi, Mohammed Ayed.
  • Rajendram R; College of Medicine, King Saud bin Abdulaziz University for Health Sciences College of Medicine, Riyadh, Al Riyadh Province, Saudi Arabia rajkumarrajendram@doctors.org.uk.
  • Alghamdi AA; Department of Medicine, King Abdulaziz Medical City, Riyadh, Al Riyadh Province, Saudi Arabia.
  • Alanazi MA; Department of Medicine, King Abdulaziz Medical City, Riyadh, Al Riyadh Province, Saudi Arabia.
BMJ Case Rep ; 15(4)2022 Apr 26.
Article in English | MEDLINE | ID: covidwho-1816729
ABSTRACT
Congenital chloride losing diarrhoea (CCLD) is a rare disease caused by mutations in an intestinal chloride/bicarbonate ion exchange channel. Few reports describe CCLD in adults and none has described the impact of a parasitic infection on CCLD. Severe diarrhoea may result in hypokalaemia with QT interval prolongation. Treatment with antiemetics may further increase the QT interval. To raise awareness of this preventable complication, we describe the course of a woman in her 20s with CCLD who developed COVID-19 and a Blastocystis hominis infestation. Treatment with antiemetics and hypokalaemia resulted in prolongation of the QT interval to 640 ms. While, the QT interval normalised with discontinuation of antiemetics and electrolyte replacement, patients with CCLD must take precautions to prevent gastrointestinal infections. Regardless, whenever patients with CCLD present to hospital, the authors recommend monitoring the QT interval and avoiding medications that predispose to torsade de pointes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Long QT Syndrome / Blastocystis hominis / COVID-19 Drug Treatment / Hypokalemia / Antiemetics Type of study: Case report / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Bcr-2021-246175

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Long QT Syndrome / Blastocystis hominis / COVID-19 Drug Treatment / Hypokalemia / Antiemetics Type of study: Case report / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Bcr-2021-246175