Acquired long QT syndrome due to antiemetics, COVID-19 and Blastocystis hominis induced exacerbation of congenital chloride losing diarrhoea.
BMJ Case Rep
; 15(4)2022 Apr 26.
Article
in English
| MEDLINE | ID: covidwho-1816729
ABSTRACT
Congenital chloride losing diarrhoea (CCLD) is a rare disease caused by mutations in an intestinal chloride/bicarbonate ion exchange channel. Few reports describe CCLD in adults and none has described the impact of a parasitic infection on CCLD. Severe diarrhoea may result in hypokalaemia with QT interval prolongation. Treatment with antiemetics may further increase the QT interval. To raise awareness of this preventable complication, we describe the course of a woman in her 20s with CCLD who developed COVID-19 and a Blastocystis hominis infestation. Treatment with antiemetics and hypokalaemia resulted in prolongation of the QT interval to 640 ms. While, the QT interval normalised with discontinuation of antiemetics and electrolyte replacement, patients with CCLD must take precautions to prevent gastrointestinal infections. Regardless, whenever patients with CCLD present to hospital, the authors recommend monitoring the QT interval and avoiding medications that predispose to torsade de pointes.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Long QT Syndrome
/
Blastocystis hominis
/
COVID-19 Drug Treatment
/
Hypokalemia
/
Antiemetics
Type of study:
Case report
/
Prognostic study
Topics:
Long Covid
Limits:
Adult
/
Female
/
Humans
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Bcr-2021-246175
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