Public health impact of covid-19 vaccines in the US: observational study.
BMJ
; 377: e069317, 2022 04 27.
Article
in English
| MEDLINE | ID: covidwho-1816732
ABSTRACT
OBJECTIVE:
To evaluate the impact of vaccine scale-up on population level covid-19 mortality and incidence in the United States.DESIGN:
Observational study.SETTING:
US county level case surveillance and vaccine administration data reported from 14 December 2020 to 18 December 2021.PARTICIPANTS:
Residents of 2558 counties from 48 US states. MAIN OUTCOMEMEASURES:
The primary outcome was county covid-19 mortality rates (deaths/100 000 population/county week). The secondary outcome was incidence of covid-19 (cases/100 000 population/county week). Incidence rate ratios were used to compare rates across vaccination coverage levels. The impact of a 10% improvement in county vaccination coverage (defined as at least one dose of a covid-19 vaccine among adults ≥18 years of age) was estimated During the eras of alpha and delta variant predominance, the impact of very low (0-9%), low (10-39%), medium (40-69%), and high (≥70%) vaccination coverage levels was compared.RESULTS:
In total, 30 643 878 cases of covid-19 and 439 682 deaths associated with covid-19 occurred over 132 791 county weeks. A 10% improvement in vaccination coverage was associated with an 8% (95% confidence interval 8% to 9%) reduction in mortality rates and a 7% (6% to 8%) reduction in incidence. Higher vaccination coverage levels were associated with reduced mortality and incidence rates during the eras of alpha and delta variant predominance.CONCLUSIONS:
Higher vaccination coverage was associated with lower rates of population level covid-19 mortality and incidence in the US.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vaccines
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Vaccines
/
Variants
Limits:
Adult
/
Humans
Country/Region as subject:
North America
Language:
English
Journal:
BMJ
Journal subject:
Medicine
Year:
2022
Document Type:
Article
Affiliation country:
Bmj-2021-069317
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