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Public health impact of covid-19 vaccines in the US: observational study.
Suthar, Amitabh Bipin; Wang, Jing; Seffren, Victoria; Wiegand, Ryan E; Griffing, Sean; Zell, Elizabeth.
  • Suthar AB; Coronavirus Disease (COVID-19) Response, Centers for Disease Control and Prevention, Atlanta, GA, USA icf4@cdc.gov.
  • Wang J; Coronavirus Disease (COVID-19) Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Seffren V; Coronavirus Disease (COVID-19) Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Wiegand RE; Coronavirus Disease (COVID-19) Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Griffing S; Coronavirus Disease (COVID-19) Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Zell E; Coronavirus Disease (COVID-19) Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
BMJ ; 377: e069317, 2022 04 27.
Article in English | MEDLINE | ID: covidwho-1816732
ABSTRACT

OBJECTIVE:

To evaluate the impact of vaccine scale-up on population level covid-19 mortality and incidence in the United States.

DESIGN:

Observational study.

SETTING:

US county level case surveillance and vaccine administration data reported from 14 December 2020 to 18 December 2021.

PARTICIPANTS:

Residents of 2558 counties from 48 US states. MAIN OUTCOME

MEASURES:

The primary outcome was county covid-19 mortality rates (deaths/100 000 population/county week). The secondary outcome was incidence of covid-19 (cases/100 000 population/county week). Incidence rate ratios were used to compare rates across vaccination coverage levels. The impact of a 10% improvement in county vaccination coverage (defined as at least one dose of a covid-19 vaccine among adults ≥18 years of age) was estimated During the eras of alpha and delta variant predominance, the impact of very low (0-9%), low (10-39%), medium (40-69%), and high (≥70%) vaccination coverage levels was compared.

RESULTS:

In total, 30 643 878 cases of covid-19 and 439 682 deaths associated with covid-19 occurred over 132 791 county weeks. A 10% improvement in vaccination coverage was associated with an 8% (95% confidence interval 8% to 9%) reduction in mortality rates and a 7% (6% to 8%) reduction in incidence. Higher vaccination coverage levels were associated with reduced mortality and incidence rates during the eras of alpha and delta variant predominance.

CONCLUSIONS:

Higher vaccination coverage was associated with lower rates of population level covid-19 mortality and incidence in the US.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Adult / Humans Country/Region as subject: North America Language: English Journal: BMJ Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Bmj-2021-069317

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Adult / Humans Country/Region as subject: North America Language: English Journal: BMJ Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Bmj-2021-069317