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Incidence and predictors of organ failure among COVID-19 hospitalized adult patients in Eastern Ethiopia. Hospital-based retrospective cohort study.
Birhanu, Abdi; Ayana, Galana Mamo; Merga, Bedasa Taye; Alemu, Addisu; Negash, Belay; Seid, Ahmed; Dessie, Yadeta.
  • Birhanu A; School of Medicine, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia. abdiibiree@gmail.com.
  • Ayana GM; School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
  • Merga BT; School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
  • Alemu A; School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
  • Negash B; School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
  • Seid A; Hiwot Fana Specialized University Hospital, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
  • Dessie Y; School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
BMC Infect Dis ; 22(1): 412, 2022 Apr 28.
Article in English | MEDLINE | ID: covidwho-1817193
ABSTRACT

BACKGROUND:

Organ failure is incapability of at least one of the body organs to carry out a normal body functions. Identifying the predictors of the organ failure is crucial for improving COVID-19 patients' survival. However, the evidence related to this information is not well-established in developing countries, including Ethiopia. Therefore, this study aimed to determine the incidence and predictors of organ failure among adult patients admitted to Hiwot Fana Specialized University Hospital (HFSUH) COVID-19 treatment center from 1st May 2020 to 20th August 2021, Eastern Ethiopia.

METHODS:

A hospital-based retrospective cohort study design was implemented. Descriptive measures such as mean with standard deviation (SD), median with interquartile range (IQR), percentages, and frequencies were computed. The binary logistic regression was used to identify the association between outcome variables (organ functional status) and independent variables with an adjusted odds ratio (AOR) at a 95% confidence interval. A significance level was declared at a p-value of less than 0.05.

RESULTS:

The mean age of study participants was 47.69 years with the standard deviation (SD) of ± 17.03. The study participants were followed for the median time of 8 days with IQR of 4, 14. The incidence of organ failure was 11.9 per 1000 person-day contribution (95% CI 9.5, 14.9). Predictors such as age above 60 years (AOR = 1.71, 95% CI 1.44, 4.53), smoking history (AOR = 5.07, 95% CI 1.39, 8.15), cardiovascular disease (AOR = 5.00, 95% CI (1.83, 11.72), and critical clinical stages of COVID-19 (AOR = 5.42, 95% 1.47, 14. 84) were significantly associated with organ failure among COVID-19 hospitalized patients.

CONCLUSIONS:

The incidence of organ failure was 11.9 per 1000 person-day contribution. Age, smoking, comorbidity, and clinical stages were significantly associated with organ failure among COVID-19 hospitalized cases. Therefore, clinicians should stringently follow the patients experiencing modifiable predictors of organ failure, especially patients with comorbidities and severe clinical stages. Moreover, the prevention programs that target elders and smokers should be strengthening to save this segment of populations before suffering from organ failure following COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / COVID-19 Drug Treatment Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Aged / Humans / Middle aged Country/Region as subject: Africa Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: S12879-022-07402-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / COVID-19 Drug Treatment Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Aged / Humans / Middle aged Country/Region as subject: Africa Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: S12879-022-07402-6