Virucidal Activity of Over-the-Counter Oral Care Products Against SARS-CoV-2.
Oral Health Prev Dent
; 20(1): 185-192, 2022 Apr 27.
Article
in English
| MEDLINE | ID: covidwho-1817913
ABSTRACT
PURPOSE:
The oral cavity is an important entry point for SARS-CoV-2 infection. This study tested whether four commercially available mouthrinses and dentifrices have in vitro virucidal activity against SARS-CoV-2 (=4 log10 reduction in viral titer). MATERIALS ANDMETHODS:
One part of stock SARS-CoV-2 virus plus one part 0.3 g/l bovine serum albumin were mixed with eight parts of test product solution. After 30 s for the rinses, or 60 s for the dentifrices, the mixture was quenched in an appropriate neutralizer, serially diluted, and inoculated onto Vero E6 cells to determine viral titer. Triplicate runs were performed for each test condition with appropriate controls for test product cytotoxicity, viral interference, and neutralizer effectiveness. Test products included 1.5% hydrogen peroxide (H2O2) rinse; 0.07% cetylpyridinium chloride (CPC) rinse; 0.454% stannous fluoride (SnF2) dentifrice A; and 0.454% SnF2 dentifrice B.RESULTS:
?The 1.5% H2O2 rinse, 0.07% CPC rinse, SnF2 dentifrice A, and SnF2 dentifrice B all produced > 4 log10 reduction in SARS-CoV-2 titer.CONCLUSION:
All four test products displayed potent virucidal activity in vitro. Clinical studies are warranted to determine what role, if any, these oral care products might play in preventing transmission of SARS-CoV-2 or in the management of patients currently diagnosed with COVID-19 illness.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Dentifrices
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Oral Health Prev Dent
Journal subject:
Dentistry
Year:
2022
Document Type:
Article
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