Molecular Aspects of Spike–ACE2 Interaction
Encyclopedia
; 2(1):96, 2022.
Article
in English
| ProQuest Central | ID: covidwho-1818060
ABSTRACT
DefinitionA new betacoronavirus (CoV-2) is responsible for the pandemic of severe acute respiratory syndrome (SARS) that began in China at the end of 2019, today known as COronaVIrus Disease 2019 (COVID-19). Subsequent studies confirmed the human angiotensin-converting enzyme 2 (hACE2) as the main cell receptor of spike trimeric glycoprotein, located on the viral envelope, mediating the CoV-2 invasion into the host cells through the receptor-binding domain (RBD) of the spike. Computational analysis of the known experimental 3D structures of spike–ACE2 complexes evidenced distinguishing features in the molecular interactions at the RBD-cell receptor binding interface between CoV-2 and previous CoV-1. The spike represents a key target for drug design as well as an optimal antigen for RNA/viral vector vaccines and monoclonal antibodies in order to maximize prevention and therapy of COVID-19.
Sciences: Comprehensive Works; COVID-19; SARS; coronavirus; CoV-1; CoV-2; viral spike protein; receptor-binding domain (RBD); human ACE2; binding interface; Infections; Severe acute respiratory syndrome coronavirus 2; Blood pressure; Disease; Mutation; Pandemics; Hypertension; Ligands; Genomes; Peptides; Enzymes; Coronaviruses; Proteins
Full text:
Available
Collection:
Databases of international organizations
Database:
ProQuest Central
Language:
English
Journal:
Encyclopedia
Year:
2022
Document Type:
Article
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