A scoping review of SARS-CoV-2 and male infertility: Concerns and future prospects
Asian Pacific Journal of Reproduction
; 11(2):53-61, 2022.
Article
in English
| EMBASE | ID: covidwho-1818348
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in the blood, urine, facial/anal swabs, semen, and vaginal discharge;all have been shown to contain SARSCoV-2 RNA. Recent findings have highlighted the prospect of SARS-CoV-2 invading the genital system in addition to other tissues, which might give rise to reproductive concerns. This investigation sheds light on male reproductive tract vulnerability to invasion by SARS-CoV-2 and provides a foundation for further researches into male fertility. Males are infected with COVID-19 at a higher rate than females. As a result, some data suggest that this viral infection might affect the male reproductive system. The probable causes for male genital tract abnormalities in COVID-19 are 1) high expression of angiotensin-converting enzyme 2 in the testes;2) SARS-CoV-2 infection indirectly induces immune response in the testes;3) SARS-CoV-2 directly damages male genital cells by virus-receptor binding activity;4) fever in SARSCoV-2 infected males may cause damages to testicular cells;5) testosterone level decreased in SAR-CoV-2 infected males;6) males are more susceptible to COVID-19 than females, which may be due to differences in the physiology of the genital tract. This review seeks to offer some insights into the potential causes of COVID-19 that affect the male reproductive system, as well as future prospect on this issue.
adult; case report; clinical article; coronavirus disease 2019; female; fever; gene expression; human; human tissue; immune response; male; male genital system; male infertility; nonhuman; orchitis; protein expression; receptor binding; review; Severe acute respiratory syndrome coronavirus 2; testis; testosterone blood level; angiotensin converting enzyme 2; endogenous compound; testosterone
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Reviews
Language:
English
Journal:
Asian Pacific Journal of Reproduction
Year:
2022
Document Type:
Article
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