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Clinical profile of hospitalized COVID-19 patients in first & second wave of the pandemic: Insights from an Indian registry based observational study.
Kumar, Gunjan; Mukherjee, Aparna; Sharma, Ravendra K; Menon, Geetha R; Sahu, Damodar; Wig, Naveet; Panda, Samiran; Rao, Vishnu Vardhan; Singh, Sujeet; Guleria, Randeep; Bhargava, Balram.
  • Kumar G; Clinical Studies, Trial & Projection Unit, Indian Council of Medical Research, New Delhi, India.
  • Mukherjee A; Clinical Studies, Trial & Projection Unit, Indian Council of Medical Research, New Delhi, India.
  • Sharma RK; ICMR-National Institute of Medical Statistics, New Delhi, India.
  • Menon GR; ICMR-National Institute of Medical Statistics, New Delhi, India.
  • Sahu D; ICMR-National Institute of Medical Statistics, New Delhi, India.
  • Wig N; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Panda S; Division of Epidemiology & Communicable Diseases, Indian Council of Medical Research, New Delhi, India.
  • Rao VV; ICMR-National Institute of Medical Statistics, New Delhi, India.
  • Singh S; National Centre for Disease Control, New Delhi, India.
  • Guleria R; All India Institute of Medical Sciences, New Delhi, India.
  • Bhargava B; Indian Council of Medical Research, New Delhi, India.
Indian J Med Res ; 153(5&6): 619-628, 2021 05.
Article in English | MEDLINE | ID: covidwho-1818381
ABSTRACT
Background &

objectives:

India witnessed a massive second surge of COVID-19 cases since March 2021 after a period of decline from September 2020. Data collected under the National Clinical Registry for COVID-19 (NCRC) were analysed to describe the differences in demographic and clinical features of COVID-19 patients recruited during these two successive waves.

Methods:

The NCRC, launched in September 2020, is an ongoing multicentre observational initiative, which provided the platform for the current investigation. Demographic, clinical, treatment and outcome data of hospitalized, confirmed COVID-19 patients were captured in an electronic data portal from 41 hospitals across India. Patients enrolled during September 1, 2020 to January 31, 2021 and February 1 to May 11, 2021 constituted participants of the two successive waves, respectively.

Results:

As on May 11, 2021, 18961 individuals were recruited in the registry, 12059 and 6903 reflecting in-patients from the first and second waves, respectively. Mean age of the patients was significantly lower in the second wave [48.7 (18.1) yr vs. 50.7 (18.0) yr, P<0.001] with higher proportion of patients in the younger age group intervals of <20, and 20-39 yr. Approximately 70 per cent of the admitted patients were ≥ 40 yr of age in both waves of the pandemic. The proportion of males were slightly lower in second wave as compared to the first [4400 (63.7%) vs. 7886 (65.4%), P=0.02]. Commonest presenting symptom was fever in both waves. In the second wave, a significantly higher proportion [2625 (48.6%) vs. 4420 (42.8%), P<0.003] complained of shortness of breath, developed ARDS [422(13%) vs. 880 (7.9%), P<0.001], required supplemental oxygen [1637 (50.3%) vs. 4771 (42.7%), P<0.001], and mechanical ventilation [260 (15.9%) vs. 530 (11.1%), P<0.001]. Mortality also significantly increased in the second wave [OR 1.35 (95% CI 1.19, 1.52)] in all age groups except in <20 yr. Interpretation &

conclusions:

The second wave of COVID-19 in India was slightly different in presentation than the first wave, with a younger demography, lesser comorbidities, and presentation with breathlessness in greater frequency.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans / Male Language: English Journal: Indian J Med Res Year: 2021 Document Type: Article Affiliation country: Ijmr.ijmr_1628_21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans / Male Language: English Journal: Indian J Med Res Year: 2021 Document Type: Article Affiliation country: Ijmr.ijmr_1628_21